CAJ | 학술논문

对脑肿瘤病人脑室内注射5mg甲氨蝶呤(MTX)3次后，脑脊液(CSF)中MTX呈二室开放动力学特点.主要动力学参数：t1/2α=3 h；t1/2β=48.2 h；Vc=15.6 mL；AUC=6365 mg.h.L-1;Cl= 0.324mL.h-1.给药后48h血药浓度很低，峰值(4h)时仅有0.7mg.L-1.对MTX经脑室给药CSF药物浓度高，维持时间久，而血药浓度一直在极低水平的原因及应用前景进行了分析.
대뇌종류병인뇌실내주사5mg갑안접령(MTX)3차후，뇌척액(CSF)중MTX정이실개방동역학특점.주요동역학삼수：t1/2α=3 h；t1/2β=48.2 h；Vc=15.6 mL；AUC=6365 mg.h.L-1;Cl= 0.324mL.h-1.급약후48h혈약농도흔저，봉치(4h)시부유0.7mg.L-1.대MTX경뇌실급약CSF약물농도고，유지시간구，이혈약농도일직재겁저수평적원인급응용전경진행료분석.
Blood-brain barrier and blood-cerebrospinal fluid(CSF) barrierare almost totally impermeable to non-lipid-soluble drugs including methotrexate(MTX). Therefore, MTX would have no effect at all on the brain when it is introduced into the blood. However, it could have excellent effects on the brain by injecting into the CSF. In this article, the pharmacokinetics of MTX in CSF was analyzed after injecting 5 mg MTX to the right cerebral ventricle of a patient with recurrent intracranial germioma, which disseminated along ependyma to ventricular system. Concentration of MTX in CSF was dramatically high, from 990 mg.L-1(0.5 h) to 80 mg*L-1(48 h). It was determined by phosphorimetric method. The mathema- tic expression of MTX concentration in CSF is: c mg.L-1=245.3 e-0.2304 t+76.22 e-0.01438 t Some main pharmacokinetic parameters were calculated as: t1/2α=3 h; t1/2β=48.2 h; Vc=15.55 mL; AUC=6365 mg.h.L-1; Cl=0.324 mL.h-1. At the same time, blood drug concentration of MTX was very low, and nearly in the same level(below 1 mg.L-1). This article also discussed the theory and prospect of chemotherapy by intraventricular injection.