CAJ | 학술논문

目的：探讨任意皮瓣掀起后血管活性因子内皮素(ET)、一氧化氮(NO)动态变化与皮瓣微循环血量的关系。方法：在猪背部两侧制备任意皮瓣，术前取背部皮肤全层测定ET、NO含量，术后取皮瓣中部皮肤全层测定；术前应用激光多谱勒血流测定仪测量背部皮肤微循环血量，术后24h持续监测皮瓣中部皮瓣微循环血量。结果：皮瓣ET、NO含量在术后1h开始明显上升，NO 3h达到峰值，ET 6h达到。皮瓣掀起后微循环血量急剧下降，1h左右下降至最低。皮瓣掀起后1、3h组织中ET含量与皮瓣微循环血量成显著负相关(γ＝－0.776，P＜0.01)，NO含量与皮瓣微循环血量成显著正相关(γ＝0.853，P＜0.01)。结论：皮瓣掀起初期ET、NO动态变化与皮瓣微循环血量密切相关。
목적：탐토임의피판흔기후혈관활성인자내피소(ET)、일양화담(NO)동태변화여피판미순배혈량적관계。방법：재저배부량측제비임의피판，술전취배부피부전층측정ET、NO함량，술후취피판중부피부전층측정；술전응용격광다보륵혈류측정의측량배부피부미순배혈량，술후24h지속감측피판중부피판미순배혈량。결과：피판ET、NO함량재술후1h개시명현상승，NO 3h체도봉치，ET 6h체도。피판흔기후미순배혈량급극하강，1h좌우하강지최저。피판흔기후1、3h조직중ET함량여피판미순배혈량성현저부상관(γ＝－0.776，P＜0.01)，NO함량여피판미순배혈량성현저정상관(γ＝0.853，P＜0.01)。결론：피판흔기초기ET、NO동태변화여피판미순배혈량밀절상관。
Objective:Six piglets were used to learn the influence of endothelin (ET) and nitric oxide (NO) on blood microcirculation in random flap.36 random flaps were elevated on the backs of these animals.Method:The microcirculatory blood flow in these flaps was continuously measured with laser Doppler velocimety at different times.Result:It was found that both ET and NO concentrations in the flaps increased significantly after elevation 1h,NO value reached the peak at 3h and ET did at 6h.But the microcirculatory blood flow decreased greatly after the elevation and reached the lowest point at 1h.There was a negative correlation between ET concentration in the flap and flap's microcirculatory blood flow (γ＝－0.776，P＜0.01),and a positive correlation between NO concentration and the flow (γ＝0.853，P＜0.01).Conclusion:It is concluded that the changes of ET and NO levels in the flaps during early elevation stage play an important role in the flap's blood microcirculation.