CAJ | 학술논문

【目的】进一步探索新近研制成功的复方抗疟药复方萘酚喹(由磷酸萘酚喹、双氢青蒿素和甲氧苄啶组成)治疗恶性疟的用药剂量。【方法】采用1d疗程2次分服，设总剂量4片组和2片组，评价和比较其疗效。两组分别治疗无并发症恶性疟患者各50例。【结果】2片组的退热时间与4片组相似，但原虫转阴时间明显慢于4片组，28d治愈率2片组(85.1%)亦显著低于4组片(97.8%)。且2片组出现早期(14d)原虫复燃，说明其药量不足。【结论】推荐复方萘酚喹治疗恶性疟的临床试验治疗总剂量采用3～4片为宜。
【목적】진일보탐색신근연제성공적복방항학약복방내분규(유린산내분규、쌍경청호소화갑양변정조성)치료악성학적용약제량。【방법】채용1d료정2차분복，설총제량4편조화2편조，평개화비교기료효。량조분별치료무병발증악성학환자각50례。【결과】2편조적퇴열시간여4편조상사，단원충전음시간명현만우4편조，28d치유솔2편조(85.1%)역현저저우4조편(97.8%)。차2편조출현조기(14d)원충복연，설명기약량불족。【결론】추천복방내분규치료악성학적림상시험치료총제량채용3～4편위의。
【Objective】To further study the efects of compound naphthoquine,anewly-developed anti-malaria drug which is composed of naphthoqu i ne phosphate,dihydroartemisinin and trimethoprim on falciparum malaria.【Method s】One-day course with a total dosage of 4 tables and 2 tables of compound naphthoquine was applied to treat falciparum malaria patients without complications.One h undred cases were subject to 4-tablet group(50,group A)and 2-tablet group(50， group B).【Results 】The mean fever-subsidence(MFS) time in group B was similar to group A,but the mean parasite clearance(MPC) time was longer than that in group A.Th e cure rate for 28 days of treatment was 85.1% in group B and 97.8% in group A.Parasite recrudescence(PR) within 14 days was found in group B,which indicated the dosage was inadequate.【Con c lusion】A total dosage of 3～4 tablets of compound naphthoquine for falciparum m alaria is recommended in the clinical trial.