CAJ | 학술논문

衰老会导致视觉功能的退化,但其潜在的神经机制尚不清楚.通过改良Golgi-Cox染色法,测定了青年雄性、青年雌性及老年雄性与老年雌性4组共20只大鼠视皮层的树突长度和树突棘密度,以研究年龄与性别对视皮层树突形态的影响.结果显示青年雄性大鼠视皮层顶树突、基树突、树突总长度均明显高于青年雌性大鼠,但这种性别差异在老年雌雄组之间并不显著,可能是由于在雄性组之间存在着明显的年龄相关性树突长度减少而在雌性组之间并不存在.青年雄性组的树突棘密度要明显高于青年雌性组, 尽管衰老导致了青年雄、雌性组的树突棘密度均明显降低,但老年雄、雌性组的树突棘密度并无显著差异,这可能是由于雄性组的年龄相关性树突密度降低程度要远大于雌性组.由此可见衰老确实能导致视皮层树突形态的退化,这可能是老年性视觉功能衰退的潜在神经机制,但这种退化可能具有一定的性别差异.
쇠로회도치시각공능적퇴화,단기잠재적신경궤제상불청초.통과개량Golgi-Cox염색법,측정료청년웅성、청년자성급노년웅성여노년자성4조공20지대서시피층적수돌장도화수돌극밀도,이연구년령여성별대시피층수돌형태적영향.결과현시청년웅성대서시피층정수돌、기수돌、수돌총장도균명현고우청년자성대서,단저충성별차이재노년자웅조지간병불현저,가능시유우재웅성조지간존재착명현적년령상관성수돌장도감소이재자성조지간병불존재.청년웅성조적수돌극밀도요명현고우청년자성조, 진관쇠로도치료청년웅、자성조적수돌극밀도균명현강저,단노년웅、자성조적수돌극밀도병무현저차이,저가능시유우웅성조적년령상관성수돌밀도강저정도요원대우자성조.유차가견쇠로학실능도치시피층수돌형태적퇴화,저가능시노년성시각공능쇠퇴적잠재신경궤제,단저충퇴화가능구유일정적성별차이.
Visual functions undergo an age-related degradation. However, the neural mechanisms underlying these changes are not yet clear. This study was designed to investigate the influence of age and sex on the anatomy of the rat's visual cortex. Dendritic tree extent and spine density were examined in young adult rats (2-3 months) and aged male and female rats (22-24 months) using a modified Golgi-Cox staining method. A sex difference in dendritic branching of the pyramidal cells was found among young adults. However, this difference disappeared during aging, due to a reduction in branching with age for males but not for females. Moreover, the pyramidal cells of young males also have a greater spine density. Although there was a reduction in spine density with age for both sexes, this reduction was more pronounced for males, resulting in a disappearance of sex difference with age. Thus these results suggest that aging could lead to the degeneration of dendrites, which might contribute to the degradation of age-related visual functions. Also the results indicate that age-related degeneration of dendrites is more severe for males than for females.