CAJ | 학술논문

背景:完善的神经支配在骨形成过程中起决定性的作用.神经损伤后可能影响正常的骨代谢,而骨的再生在一定程度上依赖其支配区域神经的再生.通过改良种植体表面结构或局部使用生长因子等可促进骨结合.目的:对神经系统支配骨代谢、失神经支配对骨骼重建的影响以及种植体植入后骨结合过程中神经支配的建立、骨感知等方面的研究进行回顾分析.方法:由第一作者检索1990/2008 PubMed数据(http://www.ncbi.him.nih.gov/PubMed)及万方数据库(http://www.wanfangdata.com.cn)有关神经系统支配骨代谢、失神经支配对骨骼重建的影响以及种植体植入后骨结合过程中神经支配的建立、骨感知等方面的文献,英文检索词为"bone metabolism,innervation,osseointegration osseoperception",中文检索词为"骨代谢,神经支配,骨结合,骨感知".排除重复性研究.计算机初检得到54篇文献,根据纳入标准保留28篇进一步归纳总结.结果与结论:神经系统发出的信号对破骨细胞和成骨细胞功能施加强有力的作用.骨膜表面普遍存在神经支配,其功能紊乱将影响骨骼的重建.骨骼中可检测出多种神经肽、神经激素、神经递质及其相关受体,揭示神经系统参与了骨的代谢和再生.种植体周围软硬组织神经支配的建立可能与骨结合、骨感知的形成密切相关.未来的研究需要进一步探索骨感知形成的解剖和神经生理病理学基础.
배경:완선적신경지배재골형성과정중기결정성적작용.신경손상후가능영향정상적골대사,이골적재생재일정정도상의뢰기지배구역신경적재생.통과개량충식체표면결구혹국부사용생장인자등가촉진골결합.목적:대신경계통지배골대사、실신경지배대골격중건적영향이급충식체식입후골결합과정중신경지배적건립、골감지등방면적연구진행회고분석.방법:유제일작자검색1990/2008 PubMed수거(http://www.ncbi.him.nih.gov/PubMed)급만방수거고(http://www.wanfangdata.com.cn)유관신경계통지배골대사、실신경지배대골격중건적영향이급충식체식입후골결합과정중신경지배적건립、골감지등방면적문헌,영문검색사위"bone metabolism,innervation,osseointegration osseoperception",중문검색사위"골대사,신경지배,골결합,골감지".배제중복성연구.계산궤초검득도54편문헌,근거납입표준보류28편진일보귀납총결.결과여결론:신경계통발출적신호대파골세포화성골세포공능시가강유력적작용.골막표면보편존재신경지배,기공능문란장영향골격적중건.골격중가검측출다충신경태、신경격소、신경체질급기상관수체,게시신경계통삼여료골적대사화재생.충식체주위연경조직신경지배적건립가능여골결합、골감지적형성밀절상관.미래적연구수요진일보탐색골감지형성적해부화신경생리병이학기출.
BACKGROUND: Consummate innervation plays an important role in bone formation. Nerve injury can impact normal bone metabolism, whereas bone regeneration depends on nerve regeneration in the innervation site to some degrees. Modified implant surface structure or usage of growth factors in local region can promote osseointegretion.OBJECTIVE: To retrospectively analyze effects of nervous system dominance bone metabolism and denervation on bone remodeling, innervated establishment and osseoperception during osseointegration following implantation.METHODS: The first author retrieved Pubmed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) (1990/2008) for publications of effects of nervous system dominance bone metabolism and denervation on bone remodeling, innervated establishment and osseoperception during osseointegration following implantation,with the key words of "bone metabolism, innervation, osseointegrationosseoperception" . Articles of repetitive contents were excluded. A total of 54 literatures were primarily obtained. According to inclusion criteria, 28 literatures were selected for summary.RESULTS AND CONCLUSION: Signals derived from the nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones, nerotransmitters and their receptors are detectable in bone, and make it clear that nervous system is involved in bone metabolism and regeneration. Establishment of innervation of soft and hard tissue around implants may play an important role in osseointegration and osseoperception. Further studies will be required to explore the basic of anatomy,neurophysiology and neuropathology, which forms osseoperception.