中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
2期
137-139
,共3页
王福军%罗亚雄%向红菊%石翔
王福軍%囉亞雄%嚮紅菊%石翔
왕복군%라아웅%향홍국%석상
心律失常%早搏%焦虑%抑郁%氟西汀
心律失常%早搏%焦慮%抑鬱%氟西汀
심률실상%조박%초필%억욱%불서정
Arthythmia%Premature beats%Anxiety%Depression%Fluxetine
目的 观察评价无器质性心脏早搏患者焦虑抑郁情况及抗抑郁药物治疗及其对患者生活质量的影响.方法 无器质性心脏早搏伴焦虑抑郁患者212例完全随机分为观察组和对照组,各106例,2组均给予美托洛尔,每次25～ 50 mg,2次/d.观察组同时给予氟西汀20～40 mg,1次/d(72例)或氟哌噻吨美利曲辛(34例),1片/次,早晨及中午各服1次,疗程2个月.治疗前后分别观察2组临床症状、心电图及焦虑自评量表(SAS)和抑郁自评量表(SDS)评分的变化,并采用“中国心血管病人生活质量评定问卷”进行生活质量评估.结果 观察组SAS、SDS评分治疗后与治疗前比较,差异有统计学意义[SAS:(39 ±9)分比(52±10)分；SDS:(39±10)分比(58 ±11)分；P＜0.01],而对照组治疗前后比较差异无统计学意义(P＞0.05)；观察组治疗后的SAS、SDS评分与对照组治疗后比较,差异有统计学意义[SAS:(39±9)分比(53±10)分；SDS:(39±10)分比(58±9)分；P＜0.01].对照组治疗后心悸、胸闷、气促、胸痛症状的改善率分别为30.2％ (32/106)、42.6％(43/101)、46.0％( 23/50)、48.6％( 17/35),观察组改善率分别为84.9％( 90/106)、95.9％ (93/97)、96.4％ (53/55)、92.1％(35/38),2组比较差异均有统计学意义(均P＜0.01).观察组心脏早搏的临床疗效为84.0％(89/106),亦明显高于对照组的53.8％ (57/106).观察组“中国心血管病人生活质量评定问卷”的得分与对照组比较,差异有统计学意义(P＜0.01).结论 心脏早搏患者伴有焦虑抑郁障碍,应用抗焦虑抑郁药物治疗能有效缓解患者的临床症状、减少早搏的发生,同时能够改善患者的生活质量.
目的 觀察評價無器質性心髒早搏患者焦慮抑鬱情況及抗抑鬱藥物治療及其對患者生活質量的影響.方法 無器質性心髒早搏伴焦慮抑鬱患者212例完全隨機分為觀察組和對照組,各106例,2組均給予美託洛爾,每次25～ 50 mg,2次/d.觀察組同時給予氟西汀20～40 mg,1次/d(72例)或氟哌噻噸美利麯辛(34例),1片/次,早晨及中午各服1次,療程2箇月.治療前後分彆觀察2組臨床癥狀、心電圖及焦慮自評量錶(SAS)和抑鬱自評量錶(SDS)評分的變化,併採用“中國心血管病人生活質量評定問捲”進行生活質量評估.結果 觀察組SAS、SDS評分治療後與治療前比較,差異有統計學意義[SAS:(39 ±9)分比(52±10)分；SDS:(39±10)分比(58 ±11)分；P＜0.01],而對照組治療前後比較差異無統計學意義(P＞0.05)；觀察組治療後的SAS、SDS評分與對照組治療後比較,差異有統計學意義[SAS:(39±9)分比(53±10)分；SDS:(39±10)分比(58±9)分；P＜0.01].對照組治療後心悸、胸悶、氣促、胸痛癥狀的改善率分彆為30.2％ (32/106)、42.6％(43/101)、46.0％( 23/50)、48.6％( 17/35),觀察組改善率分彆為84.9％( 90/106)、95.9％ (93/97)、96.4％ (53/55)、92.1％(35/38),2組比較差異均有統計學意義(均P＜0.01).觀察組心髒早搏的臨床療效為84.0％(89/106),亦明顯高于對照組的53.8％ (57/106).觀察組“中國心血管病人生活質量評定問捲”的得分與對照組比較,差異有統計學意義(P＜0.01).結論 心髒早搏患者伴有焦慮抑鬱障礙,應用抗焦慮抑鬱藥物治療能有效緩解患者的臨床癥狀、減少早搏的髮生,同時能夠改善患者的生活質量.
목적 관찰평개무기질성심장조박환자초필억욱정황급항억욱약물치료급기대환자생활질량적영향.방법 무기질성심장조박반초필억욱환자212례완전수궤분위관찰조화대조조,각106례,2조균급여미탁락이,매차25～ 50 mg,2차/d.관찰조동시급여불서정20～40 mg,1차/d(72례)혹불고새둔미리곡신(34례),1편/차,조신급중오각복1차,료정2개월.치료전후분별관찰2조림상증상、심전도급초필자평량표(SAS)화억욱자평량표(SDS)평분적변화,병채용“중국심혈관병인생활질량평정문권”진행생활질량평고.결과 관찰조SAS、SDS평분치료후여치료전비교,차이유통계학의의[SAS:(39 ±9)분비(52±10)분；SDS:(39±10)분비(58 ±11)분；P＜0.01],이대조조치료전후비교차이무통계학의의(P＞0.05)；관찰조치료후적SAS、SDS평분여대조조치료후비교,차이유통계학의의[SAS:(39±9)분비(53±10)분；SDS:(39±10)분비(58±9)분；P＜0.01].대조조치료후심계、흉민、기촉、흉통증상적개선솔분별위30.2％ (32/106)、42.6％(43/101)、46.0％( 23/50)、48.6％( 17/35),관찰조개선솔분별위84.9％( 90/106)、95.9％ (93/97)、96.4％ (53/55)、92.1％(35/38),2조비교차이균유통계학의의(균P＜0.01).관찰조심장조박적림상료효위84.0％(89/106),역명현고우대조조적53.8％ (57/106).관찰조“중국심혈관병인생활질량평정문권”적득분여대조조비교,차이유통계학의의(P＜0.01).결론 심장조박환자반유초필억욱장애,응용항초필억욱약물치료능유효완해환자적림상증상、감소조박적발생,동시능구개선환자적생활질량.
Objective To observe and assess the psychological disorders such as anxiety and depression in arrhythmic patients without organic heart disease as well as clinical efficacy and the quality of life with pharmacotherapy using antidepressants.Methods Two hundred and twelve patients with premature beats but without organic heart disease were randomly assigned to the observation group and control group with 106 patients in each group.All the patients were given with metoprolol and fluxetine or deanxit and metoprolol separately.The clinical signs、electrocardiograph( ECG),dynamic electrocardiogram( DCG),self-rating anxiety scale (SAS) and Self - rating Depression Scale (SDS) score were observed before treatment and 2 months after treatment.The Evaluation of Chinese questionnaire of quality of life in patients with cardiovascular disease was adopted to evaluate patients' quality of life.Results Compared to pre -treatment,the observation group's SAS,SDS score decreased significantly[ SAS:(39 ±9) vs (52 ± 10) ;SDS:(39 ± 10) vs (58 ± 11) ;P ＜ 0.01 ],however there were no significant changes in control group (P ＞0.05).Compared with control group,the observation group's SAS,SDS score decreased significantly [ SAS:(39 ±9) vs (53 ± 10) ;SDS:(39 ± 10) vs (58 ±9) ; P ＜0.01 ].The clinical improvement rate of observation group's symptoms regarding chest pain、thorax suffocation and breath hard were respectively 84.9％,95.9％,96.4％ and 92.1％,which were significantly higher than control group's 30.2％,42.6％,46.0％ and 48.6％( P ＜ 0.01 ).The effective rate of observation group's premature beats was 84.0％ ( 89/106),which was also significantly higher than control group's 53.8％ (57/106).The observation group's score of Evaluation of Chinese questionnaire of quality of life in patients with cardiovascular disease were significantly higher than that of control group (P ＜ 0.01 ).Conclusions The patients with premature beats who suffer from sustained cardiovascular symptom are often accompanied by psychological disorders of anxiety and depression.The quality of life in patients with premature beats with anxiety and depression can also be improved.
