中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
6期
437-438
,共2页
孙丽萍%刘海霞%卢洪文%王秀军%刘长山
孫麗萍%劉海霞%盧洪文%王秀軍%劉長山
손려평%류해하%로홍문%왕수군%류장산
糖尿病肾病%尿白蛋白排泄率%β2-微球蛋白%银杏达莫
糖尿病腎病%尿白蛋白排洩率%β2-微毬蛋白%銀杏達莫
당뇨병신병%뇨백단백배설솔%β2-미구단백%은행체막
Diabetic nephropathy%Urinary albumin excretion rate%β<,2>-microglobin%Ginkgo-Dipyridamolum
目的 观察银杏达莫注射液对早期糖尿病肾病的治疗效果.方法 将80例早期糖尿病肾病患者通过随机数字表法分为治疗组和对照组各40例.对照组给予常规治疗,治疗组在常规治疗基础上加用银杏达莫注射液20ml,静脉滴注,1次/d,共3周.治疗前后分别检测尿白蛋白排泄率,血、尿β2-微球蛋白.结果 治疗组治疗后尿蛋白排泄率为(45±21)μg/min,对照组为(96±28)μg/min;治疗组血β2-微球蛋白为(2.6±1.3)mg/L,对照组为(3.7±1.2)mg/L;尿β2-微球蛋白治疗组为(40.5±13.2)mg/L,对照组为(40.1±10.8)mg/L,与本组治疗前相比,差异有统计学意义(均P<0.05).治疗后2组尿白蛋白排泄率、血β2-微球蛋白均下降,而以治疗组更明显,2组之间差异有统计学意义.对照组治疗前血糖值(12.01±2.14)mmol/L,治疗后(7.91±2.36)mmol/L;治疗组治疗前血糖值(11.91±2.36)mmol/L,治疗后(7.81±2.89)mmol/L.2组与本组治疗前相比,差异有统计学意义(P<0/05);2组间治疗后相比,差异无统计学意义.治疗组治疗过程中未见相关药物不良反应.结论 银杏达莫注射液对早期糖尿病肾病治疗效果较好,且较安全.
目的 觀察銀杏達莫註射液對早期糖尿病腎病的治療效果.方法 將80例早期糖尿病腎病患者通過隨機數字錶法分為治療組和對照組各40例.對照組給予常規治療,治療組在常規治療基礎上加用銀杏達莫註射液20ml,靜脈滴註,1次/d,共3週.治療前後分彆檢測尿白蛋白排洩率,血、尿β2-微毬蛋白.結果 治療組治療後尿蛋白排洩率為(45±21)μg/min,對照組為(96±28)μg/min;治療組血β2-微毬蛋白為(2.6±1.3)mg/L,對照組為(3.7±1.2)mg/L;尿β2-微毬蛋白治療組為(40.5±13.2)mg/L,對照組為(40.1±10.8)mg/L,與本組治療前相比,差異有統計學意義(均P<0.05).治療後2組尿白蛋白排洩率、血β2-微毬蛋白均下降,而以治療組更明顯,2組之間差異有統計學意義.對照組治療前血糖值(12.01±2.14)mmol/L,治療後(7.91±2.36)mmol/L;治療組治療前血糖值(11.91±2.36)mmol/L,治療後(7.81±2.89)mmol/L.2組與本組治療前相比,差異有統計學意義(P<0/05);2組間治療後相比,差異無統計學意義.治療組治療過程中未見相關藥物不良反應.結論 銀杏達莫註射液對早期糖尿病腎病治療效果較好,且較安全.
목적 관찰은행체막주사액대조기당뇨병신병적치료효과.방법 장80례조기당뇨병신병환자통과수궤수자표법분위치료조화대조조각40례.대조조급여상규치료,치료조재상규치료기출상가용은행체막주사액20ml,정맥적주,1차/d,공3주.치료전후분별검측뇨백단백배설솔,혈、뇨β2-미구단백.결과 치료조치료후뇨단백배설솔위(45±21)μg/min,대조조위(96±28)μg/min;치료조혈β2-미구단백위(2.6±1.3)mg/L,대조조위(3.7±1.2)mg/L;뇨β2-미구단백치료조위(40.5±13.2)mg/L,대조조위(40.1±10.8)mg/L,여본조치료전상비,차이유통계학의의(균P<0.05).치료후2조뇨백단백배설솔、혈β2-미구단백균하강,이이치료조경명현,2조지간차이유통계학의의.대조조치료전혈당치(12.01±2.14)mmol/L,치료후(7.91±2.36)mmol/L;치료조치료전혈당치(11.91±2.36)mmol/L,치료후(7.81±2.89)mmol/L.2조여본조치료전상비,차이유통계학의의(P<0/05);2조간치료후상비,차이무통계학의의.치료조치료과정중미견상관약물불량반응.결론 은행체막주사액대조기당뇨병신병치료효과교호,차교안전.
Objective To evaluate the effect of Ginkgo-Dipyridamolum injection on early diabetic nephropathy. Methods Eighty patients with early diabetic nephropathy were divided into two groups: treatment group (n = 40) and control group (n=40). Besides routine therapy, the treatment group was also treated with Ginkgo-Dipyridamolum injection by intravenous infusion(2Oml daily). The course of treatment for both groups was 3 weeks. Urinary albumin excretion rate(UAER) ,serum and urinary β2-MG levels were measured before and after the treatment. Results After treatment, UAER and serum β2-MG levels were all decreased with a significant difference between two groups. UAER was (45±21)μg/min and(96±28)μg/min(P<0.05)in treatment group and control group respectively. Serum β2-MG was(2.6±1.3) mg/L and(3.7±1.2) mg/L in treatment group and control group respectively. (P<0.05). Conclusion Ginkgo-Dipyridamolum injection is effective for early diabetic nephropathy.
