中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
18期
1267-1269
,共3页
宁新惠%向小平%芦娜%张越溪%王文君%刘宇%周喆
寧新惠%嚮小平%蘆娜%張越溪%王文君%劉宇%週喆
저신혜%향소평%호나%장월계%왕문군%류우%주철
冠状动脉狭窄%危险因素%相关性
冠狀動脈狹窄%危險因素%相關性
관상동맥협착%위험인소%상관성
Coronary stenosis%Risk factors%Correlation
目的 研究分析冠状动脉狭窄与高血压、糖尿病、吸烟、年龄、体重、尿酸、C反应蛋白(CRP)及血脂水平之间的相关性.方法 回顾性收集我院CCU病区2005年1月到2007年6月根据Judkins法行冠状动脉造影后有冠状动脉狭窄的286例患者(男206例,女80例)的临床资料,根据造影结果,将所有患者分为单支病变组、双支病变组、3支病变或左主干病变组3组,记录患者年龄、体重、尿酸、CRP、胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯水平,经统计学分析各组与上述危险因素的关系.结果 方差分析显示,3组间年龄、LDL-C差异有统计学意义(P<0.05).3组间两两分析显示,3支或左主干病变组年龄[(62±10)岁]和LDL-C[(3.0±0.7)mmoL/L]水平均明显高于单支病变组[(59±11)岁、(2.8±0.6)mmol/L,均P<0.05].年龄、LDL-C水平与冠状动脉病变支数有相关性(r=0.163、0.149,P<0.05).结论 年龄、LDL-C水平越高越易发生冠状动脉狭窄,且年龄越大,LDL-C水平越高,越易发生3支或左主干病变.
目的 研究分析冠狀動脈狹窄與高血壓、糖尿病、吸煙、年齡、體重、尿痠、C反應蛋白(CRP)及血脂水平之間的相關性.方法 迴顧性收集我院CCU病區2005年1月到2007年6月根據Judkins法行冠狀動脈造影後有冠狀動脈狹窄的286例患者(男206例,女80例)的臨床資料,根據造影結果,將所有患者分為單支病變組、雙支病變組、3支病變或左主榦病變組3組,記錄患者年齡、體重、尿痠、CRP、膽固醇、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯水平,經統計學分析各組與上述危險因素的關繫.結果 方差分析顯示,3組間年齡、LDL-C差異有統計學意義(P<0.05).3組間兩兩分析顯示,3支或左主榦病變組年齡[(62±10)歲]和LDL-C[(3.0±0.7)mmoL/L]水平均明顯高于單支病變組[(59±11)歲、(2.8±0.6)mmol/L,均P<0.05].年齡、LDL-C水平與冠狀動脈病變支數有相關性(r=0.163、0.149,P<0.05).結論 年齡、LDL-C水平越高越易髮生冠狀動脈狹窄,且年齡越大,LDL-C水平越高,越易髮生3支或左主榦病變.
목적 연구분석관상동맥협착여고혈압、당뇨병、흡연、년령、체중、뇨산、C반응단백(CRP)급혈지수평지간적상관성.방법 회고성수집아원CCU병구2005년1월도2007년6월근거Judkins법행관상동맥조영후유관상동맥협착적286례환자(남206례,녀80례)적림상자료,근거조영결과,장소유환자분위단지병변조、쌍지병변조、3지병변혹좌주간병변조3조,기록환자년령、체중、뇨산、CRP、담고순、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、감유삼지수평,경통계학분석각조여상술위험인소적관계.결과 방차분석현시,3조간년령、LDL-C차이유통계학의의(P<0.05).3조간량량분석현시,3지혹좌주간병변조년령[(62±10)세]화LDL-C[(3.0±0.7)mmoL/L]수평균명현고우단지병변조[(59±11)세、(2.8±0.6)mmol/L,균P<0.05].년령、LDL-C수평여관상동맥병변지수유상관성(r=0.163、0.149,P<0.05).결론 년령、LDL-C수평월고월역발생관상동맥협착,차년령월대,LDL-C수평월고,월역발생3지혹좌주간병변.
Objective To study the relationship of the risk factors to the coronary artery stenosis severity in coronary atherosclerotic heart disease (CAD). Methods 286 CAD patients, 206 males and 80females, aged 61.6, underwent coronary angiography and then were divided into 3 groups according to its results: Group A with single vessel lesion, Group B with double vessel lesions, and Group C with triple/left main vessel lesions. Peripheral blood samples were collected to measure the levels of uric acid, C reactive protein, cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol, and triglyceride. Spearman correlation analysis and multiple linear regression were used to analyze the relationship between the risk factors including age, bodyweight, and blood lipids and uric acid. Results There was significant difference among the three groups at age and LDL-C ( both P ＜ 0.05 ). Age and LDL-C of Group C [ (62 ± 10), ( 3.0 ± 0.7 ) mmol/L] were significantly higher than those of Group A [ ( 59 ±11 ), (2.8 ± 0.6 ) mmol/L, both P ＜ 0.05 ]. Age ( r = 0. 163 ) and LDL-C ( r = 0. 149 ) were significantly associated with coronary artery stenosis severity ( both P ＜ 0.05 ). Conclusion The severity of coronary artery stenosis is affected by age and LDL-C. Triple/left main vessel lesions are likely to be seen in the patients with older age and higher blood level of LDL-C.
