CAJ | 학술논문

目的分析伴11p15异常的急性髓系白血病(AML)患者细胞遗传学和临床特征,并探讨其对预后的影响.方法回顾性分析1994至2010年于浙江大学医学院附属第一医院住院及门诊伴11p15异常AML患者的临床及实验室资料,并进行预后分析.结果在1725例初发AML患者中检出15例11p15异常,检出率为0.87％,其中t(7;11)异常6例,t(1;11)和t(11;12)异常各2例,t(2;11)、t(11;11)、t(11;14)、del( 11)及inv(11)异常各1例.15例11p15异常患者中,M2 10例,M53例,M1和M4各1例.6例t(7;11)异常患者均为M2型,其中5例患者白血病细胞可见Auer小体.15例患者中12例进行了化疗,7例获得缓解,但中位持续完全缓解时间仅为8(4 ～12)个月;其中13例患者均已死亡,中位生存期为11(2～19)个月.结论 11p15异常为AML中少见的再现性染色体异常,以t(7;11)最常见,并有独特的临床及实验室特征;伴11p15异常的AML患者治疗效果差,预后不良.
목적 분석반11p15이상적급성수계백혈병(AML)환자세포유전학화림상특정,병탐토기대예후적영향.방법 회고성분석1994지2010년우절강대학의학원부속제일의원주원급문진반11p15이상AML환자적림상급실험실자료,병진행예후분석.결과 재1725례초발AML환자중검출15례11p15이상,검출솔위0.87％,기중t(7;11)이상6례,t(1;11)화t(11;12)이상각2례,t(2;11)、t(11;11)、t(11;14)、del( 11)급inv(11)이상각1례.15례11p15이상환자중,M2 10례,M53례,M1화M4각1례.6례t(7;11)이상환자균위M2형,기중5례환자백혈병세포가견Auer소체.15례환자중12례진행료화료,7례획득완해,단중위지속완전완해시간부위8(4 ～12)개월;기중13례환자균이사망,중위생존기위11(2～19)개월.결론 11p15이상위AML중소견적재현성염색체이상,이t(7;11)최상견,병유독특적림상급실험실특정;반11p15이상적AML환자치료효과차,예후불량.
Objective To analyze the cytogenetic and clinical features of acute myeloid leukemia (AML) with 11 p15 abnormalities and explore its influence on prognosis.Method The clinical and laboratory data of AML patients with 1 1p15 abnormalities from the First Affiliated Hospital of Zhejiang University from 1994 to 2010 were collected and their prognosis was analyzed.Results 15 (0.87％) out of 1725 de novo AML had abnormalities of 11p15,of which 6 cases involved t(7;11 ),2 had t( 1 ;11 ) and 2 had t( 11 ;12).And others manifested t(2 ;11 ),t( 11 ; 11 ),t( 11 ; 14),del ( 11 ) or inv ( 11 ) respectively.The FAB type of 15 cases with 11p15 abnormalities were M2 ( 10 cases),M5 (3 cases),M1 (t case) and M4 ( 1 case).ALL 6 cases with t(7 ; 11 ) were M2,5 of them showed of Auer rods in myeloid blasts.12 of 15 patiets had received chemotherapy,and 7 patients obtained complete remenssion (CR),the median duration of CR was only 8 months (4 -12 months) ; Of the 15 patients,13 died,and the median overall survival (MS) was 11 months (2 - 19 months).Conclusions 11p15 abnormalities is a rare recurring chromosomal aberration in AML of which the of with the most commonly seen is t(7;11 ),which has its unique clinical and laboratory characteristics.AML patients with 11 p15 abnormalities had a poor prognosis.