CAJ | 학술논문

目的:研究三叶委陵菜乙醇提取物的镇痛作用.方法:热板法和扭体法.结果:热板法中,灌胃三叶委陵菜乙醇提取物(0.5 g/kg,1.25g/kg,2.5g/kg)15,30,60和90min后,小鼠的痛阈均明显延长,其中灌胃2.5g/kg提取物90min后的镇痛效应比氨基比林(100 mg/kg i.m.)的好.在对非甾体药敏感的扭体法中,不同剂量的三叶委陵菜醇提物(0.5 g/kg,1.25g/kg,2.5g/kg o.p.)均能显著抑制0.7%醋酸引起的扭体反应.结论:三叶委陵菜具有镇痛效应,民间用三叶委陵菜医治牙痛及其它疼痛症的疗效得到了验证.
목적:연구삼협위릉채을순제취물적진통작용.방법:열판법화뉴체법.결과:열판법중,관위삼협위릉채을순제취물(0.5 g/kg,1.25g/kg,2.5g/kg)15,30,60화90min후,소서적통역균명현연장,기중관위2.5g/kg제취물90min후적진통효응비안기비림(100 mg/kg i.m.)적호.재대비치체약민감적뉴체법중,불동제량적삼협위릉채순제물(0.5 g/kg,1.25g/kg,2.5g/kg o.p.)균능현저억제0.7%작산인기적뉴체반응.결론:삼협위릉채구유진통효응,민간용삼협위릉채의치아통급기타동통증적료효득도료험증.
Objective:To evaluate the analgesic effect from the ethanolic extract of Potentilla freyniana Bornm. var. Sinica Migo (PBSM).Methods:The analgesic properties of PBSM were investigated by the classical hot plate test and the writhing test.Results:In the hot plate test,the ethanolic extract of PBSM(0.5g/kg,1.25 g/kg,2.5g/kg,o.p.) significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2.5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).In the writhing test, which is more sensitive for non-steroidal analgesics, the ethanolic extract of PBSM (0.5g/kg,1.25g/kg,2.5g/kg o.p.) dose significantly inhibited the writhes induced by 0.7% acetic acid.Conclusion:Potentilla freyniana Bornm.var.Sinica Migo may have analgesic activity and affirm the claim by traditional medicine practitioners of the use in toothache or some painful conditions.