CAJ | 학술논문

研究表明卵泡刺激素(FSH)在卵巢癌的发生发展中通过影响缺氧诱导因子-1(HIF-1)、血管内皮生长因子(VEGF)等因子的水平对血管生成起重要的调节作用。新近研究提示FSH-FSH受体(FSHR)可能参与了肺癌等性腺外实体瘤的血管生成过程。FSH与肿瘤血管生成密切相关，可能成为抗肿瘤血管生成的新靶点。
연구표명란포자격소(FSH)재란소암적발생발전중통과영향결양유도인자-1(HIF-1)、혈관내피생장인자(VEGF)등인자적수평대혈관생성기중요적조절작용。신근연구제시FSH-FSH수체(FSHR)가능삼여료폐암등성선외실체류적혈관생성과정。FSH여종류혈관생성밀절상관，가능성위항종류혈관생성적신파점。
Recent researches show that follicle stimulating hormone (FSH) plays an important regulatory role in the angiogenesis of ovarian cancer by influencing the level of some factors such as hypoxia induce factor-1 ( HIF-1 ) ,vascular endothelial growth factor (VEGF). Meanwhile, recent studies report that FSH and FSH receptor(FSHR) may also participate in the angiogenesis of other solid tumors like lung cancer. FSH is closely related to the tumor angiogenesis, which provides a novel therapeutic target for anti-angiogenesis thera-py.