CAJ | 학술논문

药疹是药物通过注射、口服、吸入等途径进入人体后引起的皮肤黏膜反应,其临床表现多种多样,发生机制非常复杂.研究提示,细胞毒性T细胞参与多种类型药疹的发病.药疹的组织病理改变主要表现为表皮损伤,多项研究发现,表皮内T细胞在药疹的表皮损伤中发挥重要作用,概述表皮内T细胞对其表型、功能、活化调控、效应途径及其在药疹中的作用.
약진시약물통과주사、구복、흡입등도경진입인체후인기적피부점막반응,기림상표현다충다양,발생궤제비상복잡.연구제시,세포독성T세포삼여다충류형약진적발병.약진적조직병리개변주요표현위표피손상,다항연구발현,표피내T세포재약진적표피손상중발휘중요작용,개술표피내T세포대기표형、공능、활화조공、효응도경급기재약진중적작용.
Drug eruption, a mucocutaneous reaction following the entry of drugs into body through injection, oral administration or inhalation, has various clinical manifestations with complex pathogenesis. Recent studies suggest that cytotoxic T lymphocytes take part in the pathogenesis of many kinds of drug eruption. Histologically, drug eruption is characterized mainly by epidermal injury, and more and more evidence has suggested that epidermal T lymphocytes play a vital role in epidermal injury in drug eruption. This paper presents a concise description on the epitope, function, activation modulation, action pathway of epidermal T lymphocytes and their roles in drug eruption.