CAJ | 학술논문

目的探讨地区环境因素和血钙、铁、锌对儿童血铅水平的影响和干预效果.方法 ①对青岛地区3160名儿童家长进行问卷调查,包括一般项目和与血铅水平密切相关的因素.对能引起儿童铅增高的相关因素进行分析.②采用原子吸收分光光度法测定3160名儿童血铅、钙、铁、锌.将血铅增高组与非铅增高组儿童的血钙、铁、锌水平进行对比分析,并将血钙、铁、锌与血铅水平进行多元线性回归分析.③对轻度铅增高儿童分别服用钙剂、铁剂、锌剂进行干预,检测干预后血铅水平.结果 ①新居、家庭中有吸烟成员、住宅或幼儿园在工业区或交通主干道、常吃皮蛋或常喝罐装饮料的儿童铅中毒率明显增高.②铅增高儿童缺钙、铁、锌者所占比例:轻度铅增高组分别为53.31%(306/574)、46.17%(265/574)、68.47%(393/574),中度铅增高组分别为57.68%(263/456)、49.34%(225/456)、77.41%(353/456),重度铅增高组分别为64.71%(11/17)、58.82%(10/17)、82.35%(14/17),均明显高于非铅增高组[19.78%(418/2113)、5.21%(110/2113)、14.62%(309/2113)].③儿童钙、铁、锌水平与血铅水平呈负相关(回归系数分别为-0.870、-0.430、-0.565).④服用钙、铁、锌剂干预后,分别有78.32%(112/143)、66.43%(95/143)、67.83%(97/143)的轻度铅增高儿童血铅下降.结论 ①家庭有吸烟者和居住在工业区等儿童血铅增高的比例增加,血钙、铁、锌水平降低.②服用钙、铁、锌剂可使血铅下降.
목적 탐토지구배경인소화혈개、철、자대인동혈연수평적영향화간예효과.방법 ①대청도지구3160명인동가장진행문권조사,포괄일반항목화여혈연수평밀절상관적인소.대능인기인동연증고적상관인소진행분석.②채용원자흡수분광광도법측정3160명인동혈연、개、철、자.장혈연증고조여비연증고조인동적혈개、철、자수평진행대비분석,병장혈개、철、자여혈연수평진행다원선성회귀분석.③대경도연증고인동분별복용개제、철제、자제진행간예,검측간예후혈연수평.결과 ①신거、가정중유흡연성원、주택혹유인완재공업구혹교통주간도、상흘피단혹상갈관장음료적인동연중독솔명현증고.②연증고인동결개、철、자자소점비례:경도연증고조분별위53.31%(306/574)、46.17%(265/574)、68.47%(393/574),중도연증고조분별위57.68%(263/456)、49.34%(225/456)、77.41%(353/456),중도연증고조분별위64.71%(11/17)、58.82%(10/17)、82.35%(14/17),균명현고우비연증고조[19.78%(418/2113)、5.21%(110/2113)、14.62%(309/2113)].③인동개、철、자수평여혈연수평정부상관(회귀계수분별위-0.870、-0.430、-0.565).④복용개、철、자제간예후,분별유78.32%(112/143)、66.43%(95/143)、67.83%(97/143)적경도연증고인동혈연하강.결론 ①가정유흡연자화거주재공업구등인동혈연증고적비례증가,혈개、철、자수평강저.②복용개、철、자제가사혈연하강.
Objective To investigate the current status of lead(Pb) poisoning in children and correlations between Pb levels and calcium(Ca), iron(Fe), zinc(Zn) and environmental factors. Methods ①Questionnaire survey was conducted among 3160 parents in Qingdao area, regarding factors that might have effects on the levels of Pb. ②Levels of blood Pb, Ca, Fe and Zn were determined by graphite furnace atomic absorption (GFAA) spectrometry for 3160 children, who were divided into three groups: mildly increased Pb levels, moderately increased Pb levels and severely increased Pb levels, and the effects of Ca, Fe and Zn on children's blood Pb levels were analyzed by multiple linear regressions.③Children having mildly Pb increase were divided into four groups and received Ca, Fe or Zn preparations or placebo. Results ① Children living with smokers, in new houses, in houses or kindergartens located in industrial areas or main traffic roads, consuming preserved eggs or canned drinks regularly were more easily poisoned.②Percentages of children with increased levels who had insufficient blood Ca, Fe and Zn : 53.31% (306/574), 46.17% (265/574) and 68.47% (393/574), respectively, in the group of children with mildly increased Pb levels; 57.68% (263/456), 49.34% (225/456) and 77.41% (353/456), respectively, in the group of children with moderately increased Pb levels; 64.71% (11/17), 58.82% (10/17) and 82.35%(14/17), respectively, in the group of children with severely increased Pb levels. In contrast, the percentages of children in the control group who had low blood Ca, Fe and Zn were 19.78%(418/2113), 5.21% (110/2113) and 14.62%(309/2113), respectively. ③The levels of Ca, Fe and Zn had a negative correlations with blood levels of Pb(coefficient of regression were-0.870,-0.430,-0.565, respectively). ④When given Ca, Fe and Zn, the children had the blood Pb levels decreased by 78.32% (112/143), 66.43% (95/143) and 67.83% (97/143), respectively. Conclusions ①Children's increased levels of Pb have adverse effects on the absorption of Ca, Fe and Zn. ②Intaking Ca, Fe and Zn preparations can reduce blood Pb level.