CAJ | 학술논문

目的建立贫铀(depleted uranium,Du)气溶胶吸人动物模型,观察气溶胶吸入后Du在重要组织器官的蓄积情况.方法采用大鼠吸入DU气溶胶的实验模型,分别在吸入后的30、90、180、270、360和540 d,采用激光时间分辨发光分析法测定肺脏、肾脏、股骨、肝脏、心脏、脑、脾脏和胸腺等的铀含量.结果 DU气溶胶吸人后高低剂量组大鼠肺铀含量分别为(499 833.3±14 214.8)ng/g及(25 424.0 ±6193.4)ng/g,明显高于未吸入组(28.8±13.9)ng/g(P<0.05).吸入30 d后,肺、股骨及肾中的铀含量明显升高,随时间逐渐下降;吸入60 d起,肝脏、大脑、心脏、胸腺、脾脏中铀含量高于对照组,铀含量呈先升高后降低的两相分布.铀含量以肺脏、股骨、大脑、胸腺中较高,肾次之,肝、心脏、脾较少.结论 DU气溶胶吸入后,铀可在肺、肾、股骨、肝脏、大脑、心脏、胸腺、脾脏等分布,其中肺、股骨、大脑、胸腺及肾脏中高浓度铀的存在提示上述器官是DU损伤的潜在靶器官.
목적 건립빈유(depleted uranium,Du)기용효흡인동물모형,관찰기용효흡입후Du재중요조직기관적축적정황.방법 채용대서흡입DU기용효적실험모형,분별재흡입후적30、90、180、270、360화540 d,채용격광시간분변발광분석법측정폐장、신장、고골、간장、심장、뇌、비장화흉선등적유함량.결과 DU기용효흡인후고저제량조대서폐유함량분별위(499 833.3±14 214.8)ng/g급(25 424.0 ±6193.4)ng/g,명현고우미흡입조(28.8±13.9)ng/g(P<0.05).흡입30 d후,폐、고골급신중적유함량명현승고,수시간축점하강;흡입60 d기,간장、대뇌、심장、흉선、비장중유함량고우대조조,유함량정선승고후강저적량상분포.유함량이폐장、고골、대뇌、흉선중교고,신차지,간、심장、비교소.결론 DU기용효흡입후,유가재폐、신、고골、간장、대뇌、심장、흉선、비장등분포,기중폐、고골、대뇌、흉선급신장중고농도유적존재제시상술기관시DU손상적잠재파기관.
Objective To investigate the distribution of uranium in rats after inhalation with depleted uranium aerosols. Methods The depleted uranium aerosols were inhaled by Wistar rats. At 30, 90, 180, 270, 360, and 540 d after inhalation, the rata were sacrificed and tissue samples were collected. The contents of uranium in lung, kidney, liver, heart, brain, thighbone, spleen and thymus were measured by laser time-dependent spectroscopy analysis. Resulits The uranium contents of lung increased in the high-dosc and low-dose groups [(499833.3 ± 14214.8) ng/g and (25 424.0 ± 6193.4)ng/g, respectively] after inhalation, and significantly differed from the control (28.8 ± 13.9)ng/g, (P < 0.05).At 30 d after inhalation, the contents of uranium in lung, kidney and thighbone were higher than those of control, and then decreased time-dependently. At 60 d, the contents of uranium in liver, heart, brain, spleen and thymus were higher than those of control. Curve of the eontenta were biphasie, whieh went up first, reached at peak value and then went down. The contents of uranium were high in lung, thighbone, brain and thymus. Conclusions After inhalation of depleted uranium aerosols, lung and thighbone are the primary reservoirs for uranium redistributed, and accumulations in brain and thymus suggest other two organs for unanticipated injury by depleted uranium.