中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
8期
704-706
,共3页
柳文华%张兰%殷宏%罗建勋
柳文華%張蘭%慇宏%囉建勛
류문화%장란%은굉%라건훈
单相抑郁症%5-HTR2A启动区%基因多态性
單相抑鬱癥%5-HTR2A啟動區%基因多態性
단상억욱증%5-HTR2A계동구%기인다태성
Uuipolar depression%5-HT2A receptor promoter region%Gene polymorphism
目的 探讨中国西北地区汉族人群5-羟色胺2A受体[5-HTR2A(-1438A/G)]启动区基因多态性与单项抑郁症及抗抑郁药物疗效是否关联.方法 应用聚合酶链式反应(PCR)扩增技术测定136例单相抑郁症和160例正常对照的5-HTR2A(-1438A/G)基因型和等位基因,分别验证各种基因型与单项抑郁症及抗抑郁药物之间的相关性.结果 ①病例组与对照组基因型、等位基因频率差异均有统计学意义.患者A/G、G/G基因型和G等位基因频数均高于健康组(48.5%,40.6%;39.7%,34.4%;64.0%,54.7%;P＜0.05).②5-HTR2A(-1438A/G)多态性和SSRIs类抗抑郁药物盐酸帕罗西汀疗效相关,病例组中含G等位基因组与不含该等位基因组组间疗效差异有统计学意义(F=6.317,P=0.013),主要体现在第2周末(x2=5.878,P=0.015),AA组、AG组有效率均高于GG组,且AA组高于AG组(分别为87.8%,57.6%,53.7%).结论 5-HTR2A(-1438A/G)启动区基因多态性与单相抑郁症及抗抑郁药物疗效相关.G等位基因可能是单相抑郁症的易感基因,A等位基因可能是单相抑郁症的保护因子,且A等位基因与帕罗西汀的疗效佳相关.
目的 探討中國西北地區漢族人群5-羥色胺2A受體[5-HTR2A(-1438A/G)]啟動區基因多態性與單項抑鬱癥及抗抑鬱藥物療效是否關聯.方法 應用聚閤酶鏈式反應(PCR)擴增技術測定136例單相抑鬱癥和160例正常對照的5-HTR2A(-1438A/G)基因型和等位基因,分彆驗證各種基因型與單項抑鬱癥及抗抑鬱藥物之間的相關性.結果 ①病例組與對照組基因型、等位基因頻率差異均有統計學意義.患者A/G、G/G基因型和G等位基因頻數均高于健康組(48.5%,40.6%;39.7%,34.4%;64.0%,54.7%;P＜0.05).②5-HTR2A(-1438A/G)多態性和SSRIs類抗抑鬱藥物鹽痠帕囉西汀療效相關,病例組中含G等位基因組與不含該等位基因組組間療效差異有統計學意義(F=6.317,P=0.013),主要體現在第2週末(x2=5.878,P=0.015),AA組、AG組有效率均高于GG組,且AA組高于AG組(分彆為87.8%,57.6%,53.7%).結論 5-HTR2A(-1438A/G)啟動區基因多態性與單相抑鬱癥及抗抑鬱藥物療效相關.G等位基因可能是單相抑鬱癥的易感基因,A等位基因可能是單相抑鬱癥的保護因子,且A等位基因與帕囉西汀的療效佳相關.
목적 탐토중국서북지구한족인군5-간색알2A수체[5-HTR2A(-1438A/G)]계동구기인다태성여단항억욱증급항억욱약물료효시부관련.방법 응용취합매련식반응(PCR)확증기술측정136례단상억욱증화160례정상대조적5-HTR2A(-1438A/G)기인형화등위기인,분별험증각충기인형여단항억욱증급항억욱약물지간적상관성.결과 ①병례조여대조조기인형、등위기인빈솔차이균유통계학의의.환자A/G、G/G기인형화G등위기인빈수균고우건강조(48.5%,40.6%;39.7%,34.4%;64.0%,54.7%;P＜0.05).②5-HTR2A(-1438A/G)다태성화SSRIs류항억욱약물염산파라서정료효상관,병례조중함G등위기인조여불함해등위기인조조간료효차이유통계학의의(F=6.317,P=0.013),주요체현재제2주말(x2=5.878,P=0.015),AA조、AG조유효솔균고우GG조,차AA조고우AG조(분별위87.8%,57.6%,53.7%).결론 5-HTR2A(-1438A/G)계동구기인다태성여단상억욱증급항억욱약물료효상관.G등위기인가능시단상억욱증적역감기인,A등위기인가능시단상억욱증적보호인자,차A등위기인여파라서정적료효가상관.
Objective To explore the association between the 5-HTR2A (-1438A/G)promoter region gene polymorphisms and unipolar depression and effcacy of antidepressant drugs in northwest Chinese Han population.Methods Polymerase chain reaction (PCR) was used to detect the distributive frequency of serotonin 2A receptor promoter region polymorphisms of 136 unipolar depression patients( patient group) and 160 normal people tween the patient group and the control group.The frequency of AG,GG genotypes; and G allele in patients was phisms of 5-HT2AR promoter region were correlated with SSRIs treatment response(F= 6.317, P= 0.013 ).There was significant difference of the effective power at the end of week 2 ( x2 = 5.878, P= 0.015 ).The effective power of AA, AG genotype was much higher than that of GG genotype and the effective power in the group with AA genotype was higher than that with AG genotype( each 87.8% ,57.6% ,53.7% ).Conclusion The frequency of GG genotype of 5-HTR2A( 1348A/G)may be associated with episode of unipolar depression in northwest Chinese Han population and A allele may be correlated with well response to paroxetine.
