CAJ | 학술논문

目的探索顺式阿曲库胺在兔膈肌和外周肌的不同肌松效应.方法雄性新西兰兔8只,在戊巴比妥钠静脉麻醉下游离膈肌、前胫骨肌、比目鱼肌和膈神经、胫神经、腓总神经,并分别连接肌张力换能器和神经刺激电极.给予连续单次超强刺激,同步监测记录单次电刺激所诱发的肌颤搐张力.肌颤搐张力稳定后,采用累积剂量给药法静注顺式阿曲库铵,并通过监测的顺式阿曲库铵在膈肌、前胫骨肌和比目鱼肌的肌松效应强度,建立剂量-效应曲线关系,获得各肌群的ED50值和ED95值.结果顺式阿曲库铵在兔膈肌、前胫骨肌和比目鱼肌作用表现为剂量依赖性抑制增强.各肌群的ED50值和ED95值分别为:膈肌(39.3±2.5)μg/kg和(75.7±4.2)μg/kg,前胫骨肌(80.6±7.5)μg/kg和(123.3±9.3)μg/kg,比目鱼肌(80.0±7.1)μg/kg和(126.9±9.4)μg/kg.膈肌与前胫骨肌和比目鱼肌比较,差异有统计学意义(P＜0.05),前胫骨肌与比目鱼肌比较,差异无统计学意义(P＞0.05).结论顺式阿曲库铵在兔的膈肌和外周肌表现不同肌松作用,而在膈肌的肌松作用明显强于外周肌.
목적 탐색순식아곡고알재토격기화외주기적불동기송효응.방법 웅성신서란토8지,재무파비타납정맥마취하유리격기、전경골기、비목어기화격신경、경신경、비총신경,병분별련접기장력환능기화신경자격전겁.급여련속단차초강자격,동보감측기록단차전자격소유발적기전휵장력.기전휵장력은정후,채용루적제량급약법정주순식아곡고안,병통과감측적순식아곡고안재격기、전경골기화비목어기적기송효응강도,건립제량-효응곡선관계,획득각기군적ED50치화ED95치.결과 순식아곡고안재토격기、전경골기화비목어기작용표현위제량의뢰성억제증강.각기군적ED50치화ED95치분별위:격기(39.3±2.5)μg/kg화(75.7±4.2)μg/kg,전경골기(80.6±7.5)μg/kg화(123.3±9.3)μg/kg,비목어기(80.0±7.1)μg/kg화(126.9±9.4)μg/kg.격기여전경골기화비목어기비교,차이유통계학의의(P＜0.05),전경골기여비목어기비교,차이무통계학의의(P＞0.05).결론 순식아곡고안재토적격기화외주기표현불동기송작용,이재격기적기송작용명현강우외주기.
Objective To investigate the different responses of diaphragm and peripheral muscles to cisatracurium in rabbits.Methods 8 male New zealand rabbits were anaesthetized with pentobarbital,and then the diaphragm,tibialis anterior,soleus muscles,phrenic nerves,tibial nerve,and peroneal nerve were gently freeded.The muscles were secured to force displacement transducers,and the nerves were directly stimulated by electrodes with supramaximal square waves.The isometric force of twitch tention of each muscle was recorded.The cumulative dose-response technique was separately used for obtaining the ED50and ED95 values of the cisatracurium in each muscle.Results The muscle-relaxing of cisatracurium on the three muscles in were observed in a dose-dependent manner.The ED50 values and ED95 values were: diaphragm(39.3 ± 2.5)μg/kg and(75.7 ± 4.2)μg/kg,tibialis anterior(80.6 ± 7.5)μg/kg and(123.3 ±9.3)μg/kg,soleus(80.0 ± 7.1)μg/kg and(126.9 ± 9.4)μg/kg,respectively.It had significant difference between diaphragm vs tibialis or soleus,P ＜ 0.05.Conclusions The muscle relaxant effects of cisatracurium on diaphragm and peripheral muscles were different,and diaphragm was more sensitive than peripheral muscles.