中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
10期
28-30
,共3页
郭晓辉%孙艳峰%郭山春%郑振文%汤福广
郭曉輝%孫豔峰%郭山春%鄭振文%湯福廣
곽효휘%손염봉%곽산춘%정진문%탕복엄
肺炎,支原体%白细胞介素类%C反应蛋白质%免疫球蛋白类%补体C
肺炎,支原體%白細胞介素類%C反應蛋白質%免疫毬蛋白類%補體C
폐염,지원체%백세포개소류%C반응단백질%면역구단백류%보체C
Pneumonia,mycoplasma%Interleukins%C-reactive protein%Immunoglobulins%Complement C
目的 探讨检测肺炎支原体肺炎(MPP)患儿血清白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α、高敏C-反应蛋白(hs-CRP)、总免疫球蛋白(Ig)、补体C的临床意义.方法 选择61例MPP患儿(观察组)和60例健康儿童(对照组)为研究对象,IL-6、IL-8采用酶联免疫吸附试验方法测定,TNF-α采用γ放射免疫计数器检测,hs-CRP、总Ig、补体C采用速率散射比浊法测定.结果 观察组血清IL-6为(109.31±54.72)ng/L、IL-8为(128.19±65.87)ng/L、血清hs-CRP为(34.13±19.21)mg/L、总Ig为(12.62±5.51)g/L、补体C为(2.98±0.97)g/L,与对照组的(67.23±32.18)ng/L、(31.78±8.91)ng/L、(1.62±1.34)g/L、(6.71±3.65)g/L、(1.46±0.45)g/L比较均显著上升,差异有统计学意义(P＜0.05或＜0.01);两组血清TNF-α水平差异无统计学意义(P＞0.05).结论 IL-6、IL-8、hs-CRP、总Ig及补体C在小儿MPP中起重要作用,检测IL-6、IL-8、hs-CRP、总Ig及补体C的变化对判定病情和预后有一定的临床应用价值.
目的 探討檢測肺炎支原體肺炎(MPP)患兒血清白細胞介素(IL)-6、IL-8、腫瘤壞死因子(TNF)-α、高敏C-反應蛋白(hs-CRP)、總免疫毬蛋白(Ig)、補體C的臨床意義.方法 選擇61例MPP患兒(觀察組)和60例健康兒童(對照組)為研究對象,IL-6、IL-8採用酶聯免疫吸附試驗方法測定,TNF-α採用γ放射免疫計數器檢測,hs-CRP、總Ig、補體C採用速率散射比濁法測定.結果 觀察組血清IL-6為(109.31±54.72)ng/L、IL-8為(128.19±65.87)ng/L、血清hs-CRP為(34.13±19.21)mg/L、總Ig為(12.62±5.51)g/L、補體C為(2.98±0.97)g/L,與對照組的(67.23±32.18)ng/L、(31.78±8.91)ng/L、(1.62±1.34)g/L、(6.71±3.65)g/L、(1.46±0.45)g/L比較均顯著上升,差異有統計學意義(P＜0.05或＜0.01);兩組血清TNF-α水平差異無統計學意義(P＞0.05).結論 IL-6、IL-8、hs-CRP、總Ig及補體C在小兒MPP中起重要作用,檢測IL-6、IL-8、hs-CRP、總Ig及補體C的變化對判定病情和預後有一定的臨床應用價值.
목적 탐토검측폐염지원체폐염(MPP)환인혈청백세포개소(IL)-6、IL-8、종류배사인자(TNF)-α、고민C-반응단백(hs-CRP)、총면역구단백(Ig)、보체C적림상의의.방법 선택61례MPP환인(관찰조)화60례건강인동(대조조)위연구대상,IL-6、IL-8채용매련면역흡부시험방법측정,TNF-α채용γ방사면역계수기검측,hs-CRP、총Ig、보체C채용속솔산사비탁법측정.결과 관찰조혈청IL-6위(109.31±54.72)ng/L、IL-8위(128.19±65.87)ng/L、혈청hs-CRP위(34.13±19.21)mg/L、총Ig위(12.62±5.51)g/L、보체C위(2.98±0.97)g/L,여대조조적(67.23±32.18)ng/L、(31.78±8.91)ng/L、(1.62±1.34)g/L、(6.71±3.65)g/L、(1.46±0.45)g/L비교균현저상승,차이유통계학의의(P＜0.05혹＜0.01);량조혈청TNF-α수평차이무통계학의의(P＞0.05).결론 IL-6、IL-8、hs-CRP、총Ig급보체C재소인MPP중기중요작용,검측IL-6、IL-8、hs-CRP、총Ig급보체C적변화대판정병정화예후유일정적림상응용개치.
Objective To investigate the clinical significance of serum interleukin (IL)-6,IL-8,tumor necrosis factor (TNF)- α, high-sensitivity C-reactive protein (hs-C RP), total immunoglobulin (Ig) and complement C levels in children with mycoplasma pneumoniae pneumonia (MPP). Methods Sixty-one cases of children with MPP (observation group) and 60 healthy children (control group) were selected. The serum IL-6 and IL-8 levels were tested by enzyme linked immunosorbent assay(ELISA) method; the serum TNF-α level was tested by γ radioimmunoassay (RIA) counter; the serum hs-CRP, total Ig and complement C levels were tested by rate nephelometry method. Results The serum IL-6 concentration was (109.31 ±54.72) ng/L, IL-8 concentration was (128.19 ±65.87) ng/L, hs-CRP concentration was (34.13 ± 19.21) mg/L, total Ig concentration was (12.62 ± 5.51) g/L and complement C concentration was (2.98 ± 0.97) g/L in the observation group, and they were higher than those in the control group [(67.23 ±32.18) ng/L, (31.78 ±8.91) ng/L, (1.62 ±1.34) g/L, (6.71 ±3.65) g/L, (1.46 ±0.45) g/L]. The differences were significant (P ＜ 0.05 or ＜ 0.01). The serum TNF- t level between two groups had no significant difference (P＞ 0.05). Conclusions The serum cytokines IL-6 and IL-8, hs-CRP, total Ig and complement C play an important role in MPP. It has important significance to detect the serum cytokines IL-6 and IL-8, hs-CRP, total Ig and complement C levels in children with MPP.
