中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2008年
6期
472-474
,共3页
肠道病毒B型,人%疱疹病毒4型,人%巨细胞病毒%单纯疱疹病毒属%复发-缓解型多发性硬化
腸道病毒B型,人%皰疹病毒4型,人%巨細胞病毒%單純皰疹病毒屬%複髮-緩解型多髮性硬化
장도병독B형,인%포진병독4형,인%거세포병독%단순포진병독속%복발-완해형다발성경화
Enterovirus B,human%Herpesvirus 4,human%Cytomegalovirus%Simplexvirus%Relapsing-remitting multiple sclerosis
目的 探讨0EB病毒(EBV)、巨细胞病毒(CMV)、单纯疱疹病毒-1(HSV-1)、柯萨奇病毒B组Ⅰ-Ⅵ型近期活动性感染和复发.缓解型多发件硬化(RR MS)复发的关系.方法 采用酶联免疫吸附法检测34例RR MS患者和200名正常对照者血浆EB病毒、巨细胞病毒、单纯疱疹病毒-1、柯萨奇病毒B组Ⅰ-Ⅵ型IgM抗体,比较病例组和对照组间上述病毒近期活动性感染率的差别,并对病例组病毒近期活动性感染者和无活动性感染者的临床资料进行分析比较.结果 两组问EB病毒、巨细胞病毒、单纯疱疹病毒-1及柯萨奇病毒B组Ⅰ、Ⅱ、Ⅲ、Ⅵ型IgM抗体阳性率的差异无统计学意义.RR MS组和对照组间柯萨奇病毒B组Ⅳ型、Ⅴ型IgM抗体阳性的差异有统计学意义(分别为3/34和0/200,P<0.05;2/34和0/200,P<0.05).病例组中任一病毒近期活动性感染者和无活动性感染者相比,其年龄、病程、发作次数、入院体温、血白细胞分类计数(中性粒细胞、淋巴细胞和单核细胞)、糖皮质激素应用与否及EDSS分值间的差异均无统计学意义.结论 RR MS患者复发期柯萨奇病毒B组Ⅳ型、Ⅴ型近期活动性感染率较高,但近期病毒活动性感染和症状的严重度无关,未发现EBV、CMV、HSV与RR MS复发的关系.
目的 探討0EB病毒(EBV)、巨細胞病毒(CMV)、單純皰疹病毒-1(HSV-1)、柯薩奇病毒B組Ⅰ-Ⅵ型近期活動性感染和複髮.緩解型多髮件硬化(RR MS)複髮的關繫.方法 採用酶聯免疫吸附法檢測34例RR MS患者和200名正常對照者血漿EB病毒、巨細胞病毒、單純皰疹病毒-1、柯薩奇病毒B組Ⅰ-Ⅵ型IgM抗體,比較病例組和對照組間上述病毒近期活動性感染率的差彆,併對病例組病毒近期活動性感染者和無活動性感染者的臨床資料進行分析比較.結果 兩組問EB病毒、巨細胞病毒、單純皰疹病毒-1及柯薩奇病毒B組Ⅰ、Ⅱ、Ⅲ、Ⅵ型IgM抗體暘性率的差異無統計學意義.RR MS組和對照組間柯薩奇病毒B組Ⅳ型、Ⅴ型IgM抗體暘性的差異有統計學意義(分彆為3/34和0/200,P<0.05;2/34和0/200,P<0.05).病例組中任一病毒近期活動性感染者和無活動性感染者相比,其年齡、病程、髮作次數、入院體溫、血白細胞分類計數(中性粒細胞、淋巴細胞和單覈細胞)、糖皮質激素應用與否及EDSS分值間的差異均無統計學意義.結論 RR MS患者複髮期柯薩奇病毒B組Ⅳ型、Ⅴ型近期活動性感染率較高,但近期病毒活動性感染和癥狀的嚴重度無關,未髮現EBV、CMV、HSV與RR MS複髮的關繫.
목적 탐토0EB병독(EBV)、거세포병독(CMV)、단순포진병독-1(HSV-1)、가살기병독B조Ⅰ-Ⅵ형근기활동성감염화복발.완해형다발건경화(RR MS)복발적관계.방법 채용매련면역흡부법검측34례RR MS환자화200명정상대조자혈장EB병독、거세포병독、단순포진병독-1、가살기병독B조Ⅰ-Ⅵ형IgM항체,비교병례조화대조조간상술병독근기활동성감염솔적차별,병대병례조병독근기활동성감염자화무활동성감염자적림상자료진행분석비교.결과 량조문EB병독、거세포병독、단순포진병독-1급가살기병독B조Ⅰ、Ⅱ、Ⅲ、Ⅵ형IgM항체양성솔적차이무통계학의의.RR MS조화대조조간가살기병독B조Ⅳ형、Ⅴ형IgM항체양성적차이유통계학의의(분별위3/34화0/200,P<0.05;2/34화0/200,P<0.05).병례조중임일병독근기활동성감염자화무활동성감염자상비,기년령、병정、발작차수、입원체온、혈백세포분류계수(중성립세포、림파세포화단핵세포)、당피질격소응용여부급EDSS분치간적차이균무통계학의의.결론 RR MS환자복발기가살기병독B조Ⅳ형、Ⅴ형근기활동성감염솔교고,단근기병독활동성감염화증상적엄중도무관,미발현EBV、CMV、HSV여RR MS복발적관계.
Objective To study the relation between the recent active infection with Epstein-Barr virus,cytomegalovirus,herpes simplex virns-1,coxsackievirus B Ⅰ-Ⅳ and the relapse of relapsing-remitting multiple sclerosis (RR MS). Methods Using ELISA method,IgM antibodies to Epstein-Barr virus,eytomegalovirus,herpes simplex rims-1,coxsackievirus B Ⅰ-Ⅳ in the plasma from 34 RR MS patients and 200 normal controls were detected. The rates of recent active infection with the above mentioned viruses of the patients and controls were compared. For patients group,comparison was also made between the clinical data of recent active infected patients and patients without recent active infection. Results There was no statistically significant difference in positive rates of positive rates of IgM antibodies against Epstein-Barr virus,cytomegalovirus,herpes simplex virus-1 and eoxsackievirus B Ⅰ ,Ⅱ ,Ⅲ or Ⅵ between the two groups. While there was statistically significant difference in positive rates of IgM antibodies to coxsackievirus B Ⅵ and Ⅴ in the RR MS patients and those in the controls (being 3/34 and 0/200 P < 0.05;2/34 and 0/200 P < 0.05,respectively). In the patient group,when patients who had active infection with any of the viruses were compared with those who had no active infection,no significant difference between them was found in terms of age,course,frequency,body temperature on admission,differential leukocyte count (neutrophilic granulocyte,lymphocyte and monocytes),use of glucocorticoids,and EDSS point value. Conclusions There is a high rate of recent active infection with coxsackievirus B Ⅵ and Ⅴ in RR MS patients at relapsing stage. While the recent virus active infection is unrelated to the severity of the symptoms.
