中华心律失常学杂志
中華心律失常學雜誌
중화심률실상학잡지
CHINESE JOURNAL OF CARDIAC ARRHYTHMIAS
2011年
5期
354-358
,共5页
林长坚%金奇%张凝%周建%庞旸%任淑静%顾刚%吴立群
林長堅%金奇%張凝%週建%龐旸%任淑靜%顧剛%吳立群
림장견%금기%장응%주건%방양%임숙정%고강%오립군
动作电位%不应期%电生理%激动周期%心室颤动
動作電位%不應期%電生理%激動週期%心室顫動
동작전위%불응기%전생리%격동주기%심실전동
Action potentials%Refractory period%Electrophysiology%Activation cycle length%Ventricular fibrillation
目的 研究不应期离散度及激动周期变异与心室颤动(VF)诱发的关系.方法 采用6只开胸犬,在其左心室前壁心外膜缝上一块含有12×12个单极电极(电极间距2mm)的电极板.采用连续起搏方法,分别记录300 ms、200 ms及诱发VF或失去1:1心室夺获前不应期及激动周期.通过不应期标准差及其变异系数测定不应期离散度,激动周期差值的绝对值之和及其均值评估激动周期变异大小.结果 有5只犬通过此刺激方案诱发VF,VF的诱发率为83.3％.与300 ms起搏时相比,200 ms起搏时心室不应期离散度及激动周期变异差别不明显,差异无统计学意义；与300 ms及200 ms起搏时相比,VF发生或失去1∶1心室夺获前心室不应期离散度及激动周期变异显著增大,差异有统计学意义.结论 心室不应期离散度及激动周期变异与VF诱发相关,两者变异增大易于促发VF.
目的 研究不應期離散度及激動週期變異與心室顫動(VF)誘髮的關繫.方法 採用6隻開胸犬,在其左心室前壁心外膜縫上一塊含有12×12箇單極電極(電極間距2mm)的電極闆.採用連續起搏方法,分彆記錄300 ms、200 ms及誘髮VF或失去1:1心室奪穫前不應期及激動週期.通過不應期標準差及其變異繫數測定不應期離散度,激動週期差值的絕對值之和及其均值評估激動週期變異大小.結果 有5隻犬通過此刺激方案誘髮VF,VF的誘髮率為83.3％.與300 ms起搏時相比,200 ms起搏時心室不應期離散度及激動週期變異差彆不明顯,差異無統計學意義；與300 ms及200 ms起搏時相比,VF髮生或失去1∶1心室奪穫前心室不應期離散度及激動週期變異顯著增大,差異有統計學意義.結論 心室不應期離散度及激動週期變異與VF誘髮相關,兩者變異增大易于促髮VF.
목적 연구불응기리산도급격동주기변이여심실전동(VF)유발적관계.방법 채용6지개흉견,재기좌심실전벽심외막봉상일괴함유12×12개단겁전겁(전겁간거2mm)적전겁판.채용련속기박방법,분별기록300 ms、200 ms급유발VF혹실거1:1심실탈획전불응기급격동주기.통과불응기표준차급기변이계수측정불응기리산도,격동주기차치적절대치지화급기균치평고격동주기변이대소.결과 유5지견통과차자격방안유발VF,VF적유발솔위83.3％.여300 ms기박시상비,200 ms기박시심실불응기리산도급격동주기변이차별불명현,차이무통계학의의；여300 ms급200 ms기박시상비,VF발생혹실거1∶1심실탈획전심실불응기리산도급격동주기변이현저증대,차이유통계학의의.결론 심실불응기리산도급격동주기변이여VF유발상관,량자변이증대역우촉발VF.
Objective The goal of this study is to test the association between the ventricular dispersion of refractoriness and variation of activation cycle length with the induction of ventricular fibrillation (VF).Methods A plaque containing 12×12 unipolar electrodes (2 mm spacing) was sutured on the anterior epicardium of left ventricle in six open-chest beagles.The SISI restitution pacing protocol was used to evaluate the ventricular refractory periods and activation cycle lengths at the pacing cycle length (PCL) of 300 ms,200 ms and the one before inducing VF or losing 1 ∶ 1 capture.The dispersion of refractoriness was evaluated by the standard deviation and coefficient of variation of refractoriness.The variation of activation cycle length was assessed by the sum of the absolute differences of activation cycle length and its mean value.Results VF was induced in 5/6 (83.3％) beagles by this pacing protocol.Compared with the PCL of 300 ms,the ventricular dispersion of refractoriness and the variation of activation cycle length were not significantly changed by the PCL of 200 ms.However,these two parameters were significantly increased at the PCL before VF or losing 1 ∶ 1 capture compared with the PCL of 300 ms and 200 ms.Conclusion The results of the current study indicated that an increase of the ventricular dispersion of refractoriness and variation of activation cycle length could contribute to the vulnerability of VF induction.
