中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
16期
74-78
,共5页
喉肿瘤%生存素蛋白%Meta分析
喉腫瘤%生存素蛋白%Meta分析
후종류%생존소단백%Meta분석
Laryngeal neoplasm%Survivin%Meta-analysis
目的 研究生存素( Survivin)蛋白在喉癌组织中的表达及意义.方法 以“Survivin”和“喉癌”为关键词在万方数据库、中国学术期刊数据库、中文科技期刊数据库上联合检索2000年至2011年国内专业期刊发表的关于Survivin在喉癌组织中表达的独立病例对照研究的论文,并对文献进行异质性检验,以病例组与对照组比值比(OR值)为效应指标,然后应用Meta分析软件RevMan4.3对各研究原始数据进行统计处理,并计算合并OR值及95％可信区间(95％CI),同时绘制Meta分析森林图.结果 有12篇文献纳入Meta分析,累计喉癌患者605例,对照组373例.喉癌组与正常组织组OR值为26.38,95％CI为(14.97,46.47).喉癌组与癌旁组织组OR值为4.19,95％CI为(2.50,7.03).Survivin表达与喉癌临床分期(P＜0.01)、病理学分级(P＜0.01)、淋巴结转移(P＜0.05)之间存在明显相关,而与喉癌分型(P＞0.05)无明显关联.结论 对相关文献研究结果的Meta分析显示,Survivin的高表达可能在喉癌的发生、发展、转移中起重要作用,其同时可成为喉癌的恶性程度与预后的指标.
目的 研究生存素( Survivin)蛋白在喉癌組織中的錶達及意義.方法 以“Survivin”和“喉癌”為關鍵詞在萬方數據庫、中國學術期刊數據庫、中文科技期刊數據庫上聯閤檢索2000年至2011年國內專業期刊髮錶的關于Survivin在喉癌組織中錶達的獨立病例對照研究的論文,併對文獻進行異質性檢驗,以病例組與對照組比值比(OR值)為效應指標,然後應用Meta分析軟件RevMan4.3對各研究原始數據進行統計處理,併計算閤併OR值及95％可信區間(95％CI),同時繪製Meta分析森林圖.結果 有12篇文獻納入Meta分析,纍計喉癌患者605例,對照組373例.喉癌組與正常組織組OR值為26.38,95％CI為(14.97,46.47).喉癌組與癌徬組織組OR值為4.19,95％CI為(2.50,7.03).Survivin錶達與喉癌臨床分期(P＜0.01)、病理學分級(P＜0.01)、淋巴結轉移(P＜0.05)之間存在明顯相關,而與喉癌分型(P＞0.05)無明顯關聯.結論 對相關文獻研究結果的Meta分析顯示,Survivin的高錶達可能在喉癌的髮生、髮展、轉移中起重要作用,其同時可成為喉癌的噁性程度與預後的指標.
목적 연구생존소( Survivin)단백재후암조직중적표체급의의.방법 이“Survivin”화“후암”위관건사재만방수거고、중국학술기간수거고、중문과기기간수거고상연합검색2000년지2011년국내전업기간발표적관우Survivin재후암조직중표체적독립병례대조연구적논문,병대문헌진행이질성검험,이병례조여대조조비치비(OR치)위효응지표,연후응용Meta분석연건RevMan4.3대각연구원시수거진행통계처리,병계산합병OR치급95％가신구간(95％CI),동시회제Meta분석삼림도.결과 유12편문헌납입Meta분석,루계후암환자605례,대조조373례.후암조여정상조직조OR치위26.38,95％CI위(14.97,46.47).후암조여암방조직조OR치위4.19,95％CI위(2.50,7.03).Survivin표체여후암림상분기(P＜0.01)、병이학분급(P＜0.01)、림파결전이(P＜0.05)지간존재명현상관,이여후암분형(P＞0.05)무명현관련.결론 대상관문헌연구결과적Meta분석현시,Survivin적고표체가능재후암적발생、발전、전이중기중요작용,기동시가성위후암적악성정도여예후적지표.
Objective To investigate the expression and significance of survivin in laryngeal carcinoma tissue.Methods Documents published in China from 2000 to 2011 were retrieved through CNKI,VIP,and wanfang database.The inclusive criteria of studies must be the case-control ones associated with survivin and laryngeal neoplasms.Taking into account the possibilities of heterogeneity of the studies,a statistical test for heterogeneity was performed.The Meta-analysis was applied with RevMan 4.3software.Results Twelve of case-control studies were selected for this Meta-analysis with a total of 605laryngeal carcinoma cases and 372 controls included.The pooled odds ratio between laryngeal carcinoma cases and normal membrana mucosa laryngis cases was 26.38,and 95％ CI was ( 14.97,46.47 ).The pooled odds ratio between laryngeal carcinoma cases and peficancerous tissues cases was 4.19,and 95％CI was (2.50,7.03).The expression of Survivin was correlated with clinical stages (P ＜ 0.01 ),pathological differentiation (P ＜ 0.01) and lymph node metastasis (P ＜ 0.05),but was not correlated with anatomical regions (P ＞ 0.05 ).Conclusions Survivin may play an important role in the carcinogenesis,progress and metastasis of laryngeal carcinoma,which may be valuable for the diagnosis and prognosis.
