中国药学（英文版）
中國藥學（英文版）
중국약학（영문판）
JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES
2005年
4期
213-216
,共4页
贺飞%黄卉%尹富玲%李润涛%雷小平%曾慧慧
賀飛%黃卉%尹富玲%李潤濤%雷小平%曾慧慧
하비%황훼%윤부령%리윤도%뢰소평%증혜혜
DTC%抗肿瘤药物%铜
DTC%抗腫瘤藥物%銅
DTC%항종류약물%동
Dithiocarbamates (DTC)%antitumor drugs%Cu
DTC是一类具有广泛生物活性的化合物.Piperazinedithioformates具有一定的抗肿瘤活性,但其溶解性却较差.本文对一系列新型的DTC金属配合物就人体六种癌细胞系进行了体外抗肿瘤作用研究,发现了两个有较好抗肿瘤活性的化合物;并对SR-Cu进行构像研究,第一次得到了其稳定构像.
DTC是一類具有廣汎生物活性的化閤物.Piperazinedithioformates具有一定的抗腫瘤活性,但其溶解性卻較差.本文對一繫列新型的DTC金屬配閤物就人體六種癌細胞繫進行瞭體外抗腫瘤作用研究,髮現瞭兩箇有較好抗腫瘤活性的化閤物;併對SR-Cu進行構像研究,第一次得到瞭其穩定構像.
DTC시일류구유엄범생물활성적화합물.Piperazinedithioformates구유일정적항종류활성,단기용해성각교차.본문대일계렬신형적DTC금속배합물취인체륙충암세포계진행료체외항종류작용연구,발현료량개유교호항종류활성적화합물;병대SR-Cu진행구상연구,제일차득도료기은정구상.
The in vitro antitumour efficacy of some novel metal complexes of piperazinedithioformates (SR-M) was examined in six cancer cell lines. The activity was compared with that of piperazinedithioformates. Biological evaluations of a series of SR-M compounds suggest that the compounds 1c (SR-Cu) and 1f (SR-Sn) show a potent antitumor activity. The stable conformation structure of SR-Cu as a representative of SR-M was investigated and confirmed by computer workshop.
