CAJ | 학술논문

目的了解临床常见病原菌的分布及耐药现状,为临床合理使用抗生素提供参考依据.方法采用纸片扩散法进行抗生素敏感性试验.结果共分离病原菌3 202株,其中革兰阴性杆菌占78.8%,革兰阳性球菌占15.7%,真菌占5.5%.大肠埃希菌、肺炎克雷伯菌中产超广谱β-内酰胺酶(ESBLs)检出率分别为68.4%和58.3%,葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为53.6%和61.7%.碳青霉烯类抗生素对大肠埃希菌、肺炎克雷伯菌高度敏感,敏感率为100%,而对铜绿假单胞菌、鲍曼不动杆菌抗菌活性明显降低,敏感率为47.7%～71.6%,革兰阳性球菌对糖肽类和利奈唑胺抗生素高度敏感.结论细菌耐药性不断增强,应及时监测病原菌及耐药性变化趋势,加强抗生素合理使用.
목적 료해림상상견병원균적분포급내약현상,위림상합리사용항생소제공삼고의거.방법 채용지편확산법진행항생소민감성시험.결과 공분리병원균3 202주,기중혁란음성간균점78.8%,혁란양성구균점15.7%,진균점5.5%.대장애희균、폐염극뢰백균중산초엄보β-내선알매(ESBLs)검출솔분별위68.4%화58.3%,포도구균중내갑양서림금황색포도구균(MRSA)화내갑양서림응고매음성포도구균(MRCNS)적검출솔분별위53.6%화61.7%.탄청매희류항생소대대장애희균、폐염극뢰백균고도민감,민감솔위100%,이대동록가단포균、포만불동간균항균활성명현강저,민감솔위47.7%～71.6%,혁란양성구균대당태류화리내서알항생소고도민감.결론 세균내약성불단증강,응급시감측병원균급내약성변화추세,가강항생소합리사용.
Objective To investigate the pathogenic bacteria distribution and antibiotic resistance of clinical isolates from our hospital in 2009,and povide a basis for clinical treatment.Methods Antibiotic susceptibility tests were performed according tO K-B method.Results were analyzed according to CLSI 2009.and corresponding results were analyzed with WHONET 5.4 software.Resuits A total of 3202 clinical isolates were collected,of which Gram-negative organism,Gram-positive cocci and fungi accounted for 78.8%,15.7%and 5.5%,respectively.The ESBLs producing strains of Escherichia coli and Klebsiella pneumoniae accounted for 68.4%and 58.3%,respectively.Meticillin resistant strains of Staphylococcus aureus and coagulase negative Staphylococcus accounted for 53.6%and 61.7%,respectively.Escherichia coli and Klebsiella pneumoniae showed 100% susceptibility to carbopenems.But the susceptibility of Pseudomonas aeruginosa and Acinetobacter to carbopenems reduced to 47.7%～71.6%.Gram-positive cocci were highly sensitive to glycopeptides and linezolid.Conclusion Bacterial resistance increased,we should monitor pathogens and resistance change timely and strengthen the rational use of antimicrobial agents.