CAJ | 학술논문

肝脏缺血-再灌注损伤包括两个不同阶段:早期发生在再灌注2～4 h内,主要由增多的氧自由基产物所介导;晚期发生于再灌注后6 h或更久,主要由于炎症反应所致,并导致肝脏的进一步损害.肝脏的肝脏缺血-再灌注损伤是一个复杂的、多因素的过程.本综述回顾了当前对肝脏缺血-再灌注损伤的理解及研究进展,分别从微循环水平、细胞水平、分子水平阐述其机制.
간장결혈-재관주손상포괄량개불동계단:조기발생재재관주2～4 h내,주요유증다적양자유기산물소개도;만기발생우재관주후6 h혹경구,주요유우염증반응소치,병도치간장적진일보손해.간장적간장결혈-재관주손상시일개복잡적、다인소적과정.본종술회고료당전대간장결혈-재관주손상적리해급연구진전,분별종미순배수평、세포수평、분자수평천술기궤제.
Ischemia.reperfusion injury of the liver consists of two distinct phases.The early phase occurs within 2 to 4 hours after reperfusion,which may be mainly induced by the increased production of oxygen radical species.The late phase results from inflammatory responses at 6 hours or more after reperfusion,leading to the progression of liver damage.The mechanism of IRIof the liver is a complex and muhifactorial process.The review outlines the current progress in the understanding of hepatic IRI from microcirculation,cellular,andmolecular levels,respectively.