CAJ | 학술논문

目的：探讨美托洛尔控制冠状动脉搭桥术中心率的效果及安全性。方法回顾性分析40例不停跳冠状动脉搭桥术患者的临床资料。结果40例患者静脉注射美托洛尔1 min后HR开始减慢，3 min后即显著下降至(69.2±10.8)次/min，与治疗前[(85.1±13.5)次/min]差异有统计学意义(t=3.94，P＜0.01)，10 min时降到最低值(63.0±6.2)次/min，30 min后缓慢上升，但仍未超过治疗前水平；术中平均动脉压相对稳定，治疗后3 min、5min、10 min、30 min与治疗前差异无统计学意义(F=0.56，P＞0.05)。结论美托洛尔能有效控制不停跳冠状动脉搭桥术中心率变化，且不会导致血流动力学变化。
목적：탐토미탁락이공제관상동맥탑교술중심솔적효과급안전성。방법 회고성분석40례불정도관상동맥탑교술환자적림상자료。결과40례환자정맥주사미탁락이1 min후HR개시감만，3 min후즉현저하강지(69.2±10.8)차/min，여치료전[(85.1±13.5)차/min]차이유통계학의의(t=3.94，P＜0.01)，10 min시강도최저치(63.0±6.2)차/min，30 min후완만상승，단잉미초과치료전수평；술중평균동맥압상대은정，치료후3 min、5min、10 min、30 min여치료전차이무통계학의의(F=0.56，P＞0.05)。결론미탁락이능유효공제불정도관상동맥탑교술중심솔변화，차불회도치혈류동역학변화。
Objective To investigate the therapentic effect and safety by use of Metoprolol to control patients ,heart rate in off-pump coronary artery bypass graft (OPCAB). Methods Analyse the dates of 40 OPCABG patients in anesthetic stage. Results In all of the cases,when patients were treated with venous injection of Metoprolol, the heat rate obviously decreased 1 minutes later( P ＜ 0.01 ). the heat rate decreased significant to( 69.2 ± 10. 8)times/min 3 minutes later, Compared to the heat rate ( 85.1 ± 13.5) times/min of pretherapy there was statistical significance. the heat rate decreased to nadir(63.0 ± 6.2) times/min 10 minutes later. While it raised gradnally 30 minutes later,but patients'heat rate nulli-exceed. it of pretherapy. On post-treatment of 3min、5min、 10min、30min, The MAP nulli-genic marked change. Conclusion Metoprolol could control effectively patients,heat rate in OPCAB and keep hemodynamics stable.