CAJ | 학술논문

近年来,随着免疫扫描谱型分析技术的建立,T细胞受体互补决定区(TCR CDR)与HBV感染关系的研究取得了较大进展.通过对TCR CDR3谱型分析来研究HBV感染状态下克隆性和寡克隆性增生的T细胞,能进一步了解HBV感染后T细胞的免疫应答,指导疾病的免疫治疗,同时为后期T细胞表位疫苗的研制提供基础.此文就近年来TCR CDR3谱系与HBV感染的关系进行了综述.
근년래,수착면역소묘보형분석기술적건립,T세포수체호보결정구(TCR CDR)여HBV감염관계적연구취득료교대진전.통과대TCR CDR3보형분석래연구HBV감염상태하극륭성화과극륭성증생적T세포,능진일보료해HBV감염후T세포적면역응답,지도질병적면역치료,동시위후기T세포표위역묘적연제제공기출.차문취근년래TCR CDR3보계여HBV감염적관계진행료종술.
Recently, with the establishment of immunoscope spectratyping technique, great progress has been made in researching the relation between CDR3 of TCR beta chain (TCR CDR3) and HBV infection. Through the analysis of TCR CDR3 in clonal and oligoclonal expansion of T cell in patients with HBV infection, the roles of T cell immune response in HBV infection will be better understanding, so as to give some new ideas in the immunotherapy and the T cell epi-position vaccine development. The recent progress on TCR CDR3 genealogy in HBV infection is summarized in the article.