中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
1期
27-29
,共3页
杜江%范成路%孙海明%陈晗辉%赵敏
杜江%範成路%孫海明%陳晗輝%趙敏
두강%범성로%손해명%진함휘%조민
海洛因依赖%线索诱发%心理生理指标
海洛因依賴%線索誘髮%心理生理指標
해락인의뢰%선색유발%심리생리지표
Heroin dependence%Cue induce%Psycho-physiology indexDOI: 10.3760/cma.j.issn.1674-6554.2010.01.009
目的 了解环境线索诱发海洛因依赖者心理渴求及生理反应情况,探讨影响渴求反应的相关因素.方法 369名戒断时间大于1年的海洛因依赖患者观看吸毒相关视频的同时给予海洛因模拟物及吸毒用具刺激,根据被试者的自我报告,采用视觉模拟评分法评价线索诱发前与诱发后的心理渴求程度;使用生物反馈仪记录诱发前、中、后的心理与生理指标;采用冲动行为调查问卷(BIS-Ⅱ)和自制吸毒行为调查问卷评估患者冲动特质和毒品使用情况.采用重复测量方差分析和Logistic同归分析比较线索诱发前、中、后渴求变化及生理指标的差异并分析影响心理渴求的因素.结果 海洛因依赖者在环境线索诱发后心理渴求(t=11.24;P<0.01)及生理指标[心率(76.6±11.3)次/分,F=19.23;收缩压(134.4±15.8)mm Hg(1 mmHg=0.133 kPa),F=94.5;舒张压(86.9±10.6)mm Hg,F=95.0;皮导(7.48±4.25)μs,F=53.99;瞳孔t=11.73)改变显著(P<0.01).Logistic回归分析显示,冲动特质得分高的被试者更容易诱发出心理渴求(P=0.001,95%CI:1.015～1.065).结论 长期戒断的海洛因依赖患者在环境线索诱发下仍存在明显的心理渴求;冲动特质对环境线索诱发的渴求反应影响显著.
目的 瞭解環境線索誘髮海洛因依賴者心理渴求及生理反應情況,探討影響渴求反應的相關因素.方法 369名戒斷時間大于1年的海洛因依賴患者觀看吸毒相關視頻的同時給予海洛因模擬物及吸毒用具刺激,根據被試者的自我報告,採用視覺模擬評分法評價線索誘髮前與誘髮後的心理渴求程度;使用生物反饋儀記錄誘髮前、中、後的心理與生理指標;採用遲動行為調查問捲(BIS-Ⅱ)和自製吸毒行為調查問捲評估患者遲動特質和毒品使用情況.採用重複測量方差分析和Logistic同歸分析比較線索誘髮前、中、後渴求變化及生理指標的差異併分析影響心理渴求的因素.結果 海洛因依賴者在環境線索誘髮後心理渴求(t=11.24;P<0.01)及生理指標[心率(76.6±11.3)次/分,F=19.23;收縮壓(134.4±15.8)mm Hg(1 mmHg=0.133 kPa),F=94.5;舒張壓(86.9±10.6)mm Hg,F=95.0;皮導(7.48±4.25)μs,F=53.99;瞳孔t=11.73)改變顯著(P<0.01).Logistic迴歸分析顯示,遲動特質得分高的被試者更容易誘髮齣心理渴求(P=0.001,95%CI:1.015～1.065).結論 長期戒斷的海洛因依賴患者在環境線索誘髮下仍存在明顯的心理渴求;遲動特質對環境線索誘髮的渴求反應影響顯著.
목적 료해배경선색유발해락인의뢰자심리갈구급생리반응정황,탐토영향갈구반응적상관인소.방법 369명계단시간대우1년적해락인의뢰환자관간흡독상관시빈적동시급여해락인모의물급흡독용구자격,근거피시자적자아보고,채용시각모의평분법평개선색유발전여유발후적심리갈구정도;사용생물반궤의기록유발전、중、후적심리여생리지표;채용충동행위조사문권(BIS-Ⅱ)화자제흡독행위조사문권평고환자충동특질화독품사용정황.채용중복측량방차분석화Logistic동귀분석비교선색유발전、중、후갈구변화급생리지표적차이병분석영향심리갈구적인소.결과 해락인의뢰자재배경선색유발후심리갈구(t=11.24;P<0.01)급생리지표[심솔(76.6±11.3)차/분,F=19.23;수축압(134.4±15.8)mm Hg(1 mmHg=0.133 kPa),F=94.5;서장압(86.9±10.6)mm Hg,F=95.0;피도(7.48±4.25)μs,F=53.99;동공t=11.73)개변현저(P<0.01).Logistic회귀분석현시,충동특질득분고적피시자경용역유발출심리갈구(P=0.001,95%CI:1.015～1.065).결론 장기계단적해락인의뢰환자재배경선색유발하잉존재명현적심리갈구;충동특질대배경선색유발적갈구반응영향현저.
Objective To understand the cue-induced craving, physiological reactions to heroin-related cues, and to explore the factors that impact the cue-induced craving. Methods 369 abstinent heroin addicts were exposed to videotapes of heroin using and simulacrum after the self relaxation. The craving, abstinent symp-toms were measured before and after cue exposures. The physiological reactions were measured by multi-biofeed-back instrument before, during, and after cue exposure. BIS-Ⅱ questionnaire was used to collect information about their impulsive characteristic. Results After cue exposure, the self-reports scores of craving (t=11.24, P< 0.01), physiological index including heart rate((76.6±11.3) beats/min, F=19.23), skin conduct ((7.48± 4.25)μs, F=53.99), pupil size (t=11.73) had significant change in heroin addicts (P<0.01). Logistic regres-sion results showed that the scores of BIS-Ⅱ were related to cue-reduced craving (P=0.001,95% CI: 1.015～1. 065). Conclusions Exposure to drug-related cues can induces craving and physiological reactions in long term abstinence heroin addicts. High impulsive characteristic is a risk factor to induce drug-related craving. The inter-vention strategies should consider the impulsive characteristic and make a comprehensive intervention program to prevent relapse.
