CAJ | 학술논문

目的研究特发性全身强直-阵挛发作(GTCS)患儿智商(IQ)及影响因素.方法选择皖南区20个GTCS家系中所有28名年龄在9～16岁GTCS患儿作为癫痫组,与年龄、性别可比的同胞(对照组1)及同村健康儿童(对照组2)相比较,研究3组儿童的IQ及GTCS患儿智商的影响因素,所有数据用SPSS12.0进行分析.P＜0.05为有统计学意义.结果 ①癫痫组儿童的平均总智商[(85.64±20.57)分]比对照组1[(103.39±11.17)分]及对照组2[(106.17±11.67)分]低.除填图与图片排列外,癫痫组的所有其他分测验得分均低于两对照组,差异具有统计学意义(P＜0.01).②对照组1与对照组2之间的IQ及各分测验得分差异无统计学意义.③GTCS患儿IQ与父亲受教育程度(r=0.453,P＜0.01)、癫痫发病年龄( r=0.506,P＜0.01)、癫痫发作病程(即自第1次癫痫发作至最后1次发作的时间阶段,r=-0.533,P＜0.01)、癫痫发作频率(r=-0.708,P＜0.01)、癫痫持续状态(r=-0.732,P＜0.01)显著相关.结论特发性GTCS患儿IQ明显低于同胞及一般健康儿童；影响GTCS患儿IQ的癫痫相关变量有癫痫发作病程、癫痫持续状态、癫痫发病年龄、总的癫痫发作次数、癫痫发作频率.
목적 연구특발성전신강직-진련발작(GTCS)환인지상(IQ)급영향인소.방법 선택환남구20개GTCS가계중소유28명년령재9～16세GTCS환인작위전간조,여년령、성별가비적동포(대조조1)급동촌건강인동(대조조2)상비교,연구3조인동적IQ급GTCS환인지상적영향인소,소유수거용SPSS12.0진행분석.P＜0.05위유통계학의의.결과 ①전간조인동적평균총지상[(85.64±20.57)분]비대조조1[(103.39±11.17)분]급대조조2[(106.17±11.67)분]저.제전도여도편배렬외,전간조적소유기타분측험득분균저우량대조조,차이구유통계학의의(P＜0.01).②대조조1여대조조2지간적IQ급각분측험득분차이무통계학의의.③GTCS환인IQ여부친수교육정도(r=0.453,P＜0.01)、전간발병년령( r=0.506,P＜0.01)、전간발작병정(즉자제1차전간발작지최후1차발작적시간계단,r=-0.533,P＜0.01)、전간발작빈솔(r=-0.708,P＜0.01)、전간지속상태(r=-0.732,P＜0.01)현저상관.결론 특발성GTCS환인IQ명현저우동포급일반건강인동；영향GTCS환인IQ적전간상관변량유전간발작병정、전간지속상태、전간발병년령、총적전간발작차수、전간발작빈솔.
Objective To study the intelligence quotient(IQ) profile of the children with idiopathic generalized tonic-clonic seizure (GTCS) and the factors influencing IQ of them.Methods All 28 children with GTCS were selected who were aged 9 ～ 16 years in 20 GTCS families in a mountain area of the south of Anhui Province,all available healthy siblings of the children included in the epilepsy group,did not have epilepsy,and were nearest in age to the children with GTCS ( control group 1 ),and thirty children aged 9 ～ 16 years old who had lived in the same village ( control group 2) entered into our study.The IQ was studied of the three groups of children and the factors influencing IQ of children with GTCS at the same time.The data were input SPSS12.0 and analyzed.Results The IQ of children with GTCS(85.64 ±20.57)was lower than that control group 1( 103.39 ± 11.17)and the control group 2 ( 106.17 ± 11.67).The difference between children with GTCS and the two control groups were significant for almost all the subtest quotients except completion of drawing and picture arrangement.No significant differences were found between the control group 1 and the control group 2 on the IQ and the subtest quotients.IQ scores of children with GTCS showed significant linear correlation with father's education( r=0.453,P＜0.01 ),age at onset of epilepsy( r=0.506,P＜0.01 ),duration of seizure disorder( r=-0.533,P＜0.0l ),status epilepticus( r=-0.732,P＜0.01),total number of seizures( r=-0.761,P＜0.01) and seizure frequency ( r=-0.708,P ＜ 0.01 ).Conclusion The IQ scores of the children with idiopathic GTCS are lower significantly than general children population.Epilepsy-related variables affecting IQ scores of the children with idiopathic GTCS are duration of seizure disorder,status epilepticus,age at onset of epilepsy,total number of seizures,seizure frequency.