CAJ | 학술논문

目的探讨次声不同时间作用后大鼠肾脏组织病理和超微结构的变化.方法将20只Sprague-Dawley大鼠随机分为正常对照组、假次声作用组、次声作用A组和次声作用B组.次声作用A组(2 h/d,连续作用7 d)和次声作用B组(4 h/d,连续作用7 d)大鼠反复暴露于16 Hz、130 dB的次声环境中.用光镜、扫描电镜和透射电镜观察各组大鼠肾脏组织病理和超微结构的变化.结果光镜下,次声作用A组局部肾小球囊腔增大,肾小管上皮细胞脱落;次声作用B组出现轻度肾小管变性坏死,肾小球毛细血管扩张.管腔内可见少量渗出.电镜下,次声作用B组有大量溶酶体增生,间质水肿.白细胞附壁;次声作用A组和次声作用B组均有局部足细胞突水肿、融合,线粒体空泡化等变化.结论次声每天长时间作用于大鼠,对其肾脏组织病理和超微结构损害较短时间作用严重.
목적 탐토차성불동시간작용후대서신장조직병리화초미결구적변화.방법 장20지Sprague-Dawley대서수궤분위정상대조조、가차성작용조、차성작용A조화차성작용B조.차성작용A조(2 h/d,련속작용7 d)화차성작용B조(4 h/d,련속작용7 d)대서반복폭로우16 Hz、130 dB적차성배경중.용광경、소묘전경화투사전경관찰각조대서신장조직병리화초미결구적변화.결과 광경하,차성작용A조국부신소구낭강증대,신소관상피세포탈락;차성작용B조출현경도신소관변성배사,신소구모세혈관확장.관강내가견소량삼출.전경하,차성작용B조유대량용매체증생,간질수종.백세포부벽;차성작용A조화차성작용B조균유국부족세포돌수종、융합,선립체공포화등변화.결론 차성매천장시간작용우대서,대기신장조직병리화초미결구손해교단시간작용엄중.
Objective To investigate renal tissue changes in rats exposed to 16 Hz/130 dB infrasound.Methods Twenty male Sprague-Dawley adult rats were randomly divided into a control group,a pseudo-infrasound group,and two infrasound groups-A and B.Groups A and B were exposed to 16 Hz/130 dB infrasound for 2 h or4 h daily respectively over 7 days.Pathological and uhrastruetural changes in their renal tissues were observed with a light microscope and an electron microscope.Results Under the light microscope,Bowman's capsules expanded,epithelial cells were shed,and a little secretion was found in the renal tubules of infrasound group A.Slight degeneration and necrosis of the renal tubules and glomerular exudation could be observed in group B.Under the electron microscope,a large number of lysosomes displayed hyperplasia,there was interstitial edema,and leukocyte pavementing wag found in group B.Other changes such as swelling of podocytes' processes,fusion of foot processes,and vacuolization in the mitochondria could be observed in both infrasound groups.Conclusion Lengthy exposure to 16 Hz/130 dB infrasound can cause severe pathological and uhrastruetural changes in renal tissue,at least in rats.