CAJ | 학술논문

目的　探讨血清Ⅳ型胶原测定在诊断肝纤维化中的应用价值。方法　用ELISA法测定209例各型病毒性肝炎患者及53例健康体检者血清Ⅳ型胶原的水平。结果　血清Ⅳ型胶原水平在慢性肝炎中度患者明显升高，以慢性肝炎重度和肝硬化患者最高，三组患者与其他组比较差异有显著性(P<0．01)，其升高程度与肝纤维化程度及肝病的严重程度呈正相关。结论　血清Ⅳ型胶原测定可以作为反映慢性肝病纤维化严重程度和预后的指标。
목적　탐토혈청Ⅳ형효원측정재진단간섬유화중적응용개치。방법　용ELISA법측정209례각형병독성간염환자급53례건강체검자혈청Ⅳ형효원적수평。결과　혈청Ⅳ형효원수평재만성간염중도환자명현승고，이만성간염중도화간경화환자최고，삼조환자여기타조비교차이유현저성(P<0．01)，기승고정도여간섬유화정도급간병적엄중정도정정상관。결론　혈청Ⅳ형효원측정가이작위반영만성간병섬유화엄중정도화예후적지표。
Objective To study the clinical significance of serum type Ⅳ collagen( Ⅳ - C) levelsfor the diagnosis of hepatic fibrosis. Methods Serum levels of Ⅳ - C were measured in 209 patientswith viral hepatitis and 53 healthy persons by ELISA. Results Compared with the normal group,the serum Ⅳ - C level was significantly increased in patients with chronic moderate hepatitis and wasthe highest in patients with chronic severe hepatitis and hepatic cirrhosis( P < 0.01 ). There was no sig-nificant difference in the serum Ⅳ- C level among acute viral hepatitis, chronic mild hepatitis and con-trols ( P >0.05). There was significant difference in the serum Ⅳ - C level in patients with hepaticcirrhosis by Child- Pugh grading( P < 0.01 ). The serum Ⅳ - C level was positively correlated withthe degree of hepatic fibrosis and the severity of hepatic diseases. Conclusion The meastrement of serumⅣ- C may be useful for assessment of the degree of hepatic fibrosis and progrosis of chronic hepatitis.