CAJ | 학술논문

［目的］研制车间空气中乙酰甲胺磷的国家卫生标准。［方法］乙酰甲胺磷动物毒性试验及接触工人的职业流行病学调查。［结果］乙酰甲胺磷大鼠经口LD50为823 mg/kg。致突变性试验、致畸试验及迟发性神经毒性试验均为阴性。车间空气中乙酰甲胺磷浓度测定大多数在0.5 mg/m3以下，未发现接触工人有中毒症状。［结论］建议车间空气中乙酰甲胺磷的最高容许浓度为0.5 mg/m3，其时间加权平均容许浓度为0.3 mg/m3。
［목적］연제차간공기중을선갑알린적국가위생표준。［방법］을선갑알린동물독성시험급접촉공인적직업류행병학조사。［결과］을선갑알린대서경구LD50위823 mg/kg。치돌변성시험、치기시험급지발성신경독성시험균위음성。차간공기중을선갑알린농도측정대다수재0.5 mg/m3이하，미발현접촉공인유중독증상。［결론］건의차간공기중을선갑알린적최고용허농도위0.5 mg/m3，기시간가권평균용허농도위0.3 mg/m3。
［Objective］ To establish national health standard for acephate in the air of workplace.［Method］Occupational epidemiological investigation in field and animal experiments were performed to study the toxicity of acephate. ［Results］ LD50 for acephate by intragastric administration is 823 mg/kg in rats. Negative effects were obtained in experimental assays of mutagenicity,teratogenicity and delayed neurotoxicity.The results of determination showed that most of the acephate concentrations in the air of workplaces were below 0.5 mg/m3.The signs of adverse effects of acephate poisoning in workers were not fuond. ［Conclusion］ The maximum allowable concentration(MAC) and the time-weighted average allowable concentration(TWA-AC) were recommended as 0.5 mg/m3 and 0.3 mg/m3,respectively.