中德临床肿瘤学杂志(英文版)
中德臨床腫瘤學雜誌(英文版)
중덕림상종류학잡지(영문판)
THE CHINESE-GERMAN JOURNAL OF CLINICAL ONCOLOGY
2006年
5期
316-318
,共3页
江启安%周毅得%程桂娥%Fangyun Gong%Shuyan Zhang%Fengping Lang%Meihong Zhao
江啟安%週毅得%程桂娥%Fangyun Gong%Shuyan Zhang%Fengping Lang%Meihong Zhao
강계안%주의득%정계아%Fangyun Gong%Shuyan Zhang%Fengping Lang%Meihong Zhao
pericardial effusion%lung cancer%highly agglutinative staphylococcin
Objective: To evaluate the therapeutic efficacy of injecting highly agglutinative staphylococcin (HASL) and cisplatin into pericardial cavity of lung cancer patients with pericardial effusion.Methods: 81 patients were randomized into two groups:45 in the experimental group (HASL and Cisplatin) and 36 in the control group (Cisplatin).At first pericardial effusion was drained out from a intrapericardial catheter and then different drugs were infused,respectively.24 h after perfusion the draining continued again until drainage quantity was less than 30 mL every day.The draining lasted 10-15 days.Results: The response rate was 91.1% for the experimental group and 80.6% for the control group.There was no significant difference between the two groups(P>0.05).The complete remission was 77.8% for the experimental group and 52.8% for the control group,which was statistically significant difference (P<0.05).The adverse effects were myelosuppression and nausea and vomiting,which were 35.6% and 40.0% in the experimental group and 72.2% and 66.7% in the control group,respectively (P<0.01,P<0.05).Conclusion: Injecting HASL and cisplatin into pericardial cavity may be a better way to control pericardial effusion of lung cancer.