CAJ | 학술논문

瘙痒的产生是一个复杂的多因素作用的结果,其具体机制尚不完全清楚.研究已证实,瘙痒具有特异的神经传导通路,多种内源性物质与瘙痒的发病密切相关.近年来的研究表明,组胺4型受体、蛋白酶活化受体-2、白介素-31受体、神经激肽受体-1在皮肤无髓C神经纤维的表达可能介导瘙痒的发生,而神经营养素和神经生长因子及其受体则可能作为一种瘙痒敏感剂,促进瘙痒的形成与发展.这些化学介质及其受体在瘙痒发生的病理生理机制中并不是孤立地起作用,而是与神经细胞、免疫细胞及皮肤细胞紧密联系.
소양적산생시일개복잡적다인소작용적결과,기구체궤제상불완전청초.연구이증실,소양구유특이적신경전도통로,다충내원성물질여소양적발병밀절상관.근년래적연구표명,조알4형수체、단백매활화수체-2、백개소-31수체、신경격태수체-1재피부무수C신경섬유적표체가능개도소양적발생,이신경영양소화신경생장인자급기수체칙가능작위일충소양민감제,촉진소양적형성여발전.저사화학개질급기수체재소양발생적병리생리궤제중병불시고입지기작용,이시여신경세포、면역세포급피부세포긴밀련계.
Itch results from complex interaction among multiple factors.The exact mechanism of itch is still unknown.It has been evidenced that itch is related to specific neural pathways.A variety of endogenous mediators have proved to be associated with the pathogenesis of pruritus.Recent studies have demonstrated that the expression of histamine 4 receptor,protease-activated receptor-2,interleukin-31 receptor and neurokinin-1 receptor in afferent nerve fibers of skin may mediate the occurrence of itch.Neurotrophins,nerve growth factors and their receptors may serve as a sensitizer to promote the occurrence and development of pruritus.These mediators and their receptors are not independent,but closely contact with nerve cells,immune cells and skin cells,in the pathophysiological mechanism of itch.