中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
21期
7-9
,共3页
廖新学%李欣%王礼春%何健桂%董吁刚%杜志民%马虹
廖新學%李訢%王禮春%何健桂%董籲剛%杜誌民%馬虹
료신학%리흔%왕례춘%하건계%동우강%두지민%마홍
血栓调节蛋白%内皮细胞%冠脉综合征
血栓調節蛋白%內皮細胞%冠脈綜閤徵
혈전조절단백%내피세포%관맥종합정
Thrombomodulin%Endothelial cells%Coronary syndrome
目的 测定急性冠脉综合征(ACS)患者可溶性血栓调节蛋白(sTM)水平并探讨其临床意义.方法 用ELISA法测定48例ACS患者(ACS组)及10例对照者(对照组)sTM水平,并对冠状动脉造影结果、各种冠心病危险因子和主要心脏不良事件与sTM水平之间的关系进行统计分析.结果 ACS组sTM水平高于对照组[(3.674±71)μg/L比(2.34±0.43)μg/L,P<0.05].危险因子数>2个患者的sTM水平高于危险因子数≤2个患者[(4.93±2.76)μg/L比(3.13±0.81)μg/L,P<0.05];病变血管数>2支患者的sTM水平高于病变血管数≤2支患者[(4.60±2.83)μg/L比(2.91±0.23)μg/L,P<0.05].sTM>3.2 μg/L患者的主要心脏不良事件发生率显著高于sTM≤3.2 μg/L患者(70.0%比35.7%,P<0.05).结论 sTM水平是反映内皮细胞损伤程度和范围的良好标志,它与冠心病危险因子的损伤作用有关,并对ACS的病变范围和预后有提示意义.
目的 測定急性冠脈綜閤徵(ACS)患者可溶性血栓調節蛋白(sTM)水平併探討其臨床意義.方法 用ELISA法測定48例ACS患者(ACS組)及10例對照者(對照組)sTM水平,併對冠狀動脈造影結果、各種冠心病危險因子和主要心髒不良事件與sTM水平之間的關繫進行統計分析.結果 ACS組sTM水平高于對照組[(3.674±71)μg/L比(2.34±0.43)μg/L,P<0.05].危險因子數>2箇患者的sTM水平高于危險因子數≤2箇患者[(4.93±2.76)μg/L比(3.13±0.81)μg/L,P<0.05];病變血管數>2支患者的sTM水平高于病變血管數≤2支患者[(4.60±2.83)μg/L比(2.91±0.23)μg/L,P<0.05].sTM>3.2 μg/L患者的主要心髒不良事件髮生率顯著高于sTM≤3.2 μg/L患者(70.0%比35.7%,P<0.05).結論 sTM水平是反映內皮細胞損傷程度和範圍的良好標誌,它與冠心病危險因子的損傷作用有關,併對ACS的病變範圍和預後有提示意義.
목적 측정급성관맥종합정(ACS)환자가용성혈전조절단백(sTM)수평병탐토기림상의의.방법 용ELISA법측정48례ACS환자(ACS조)급10례대조자(대조조)sTM수평,병대관상동맥조영결과、각충관심병위험인자화주요심장불량사건여sTM수평지간적관계진행통계분석.결과 ACS조sTM수평고우대조조[(3.674±71)μg/L비(2.34±0.43)μg/L,P<0.05].위험인자수>2개환자적sTM수평고우위험인자수≤2개환자[(4.93±2.76)μg/L비(3.13±0.81)μg/L,P<0.05];병변혈관수>2지환자적sTM수평고우병변혈관수≤2지환자[(4.60±2.83)μg/L비(2.91±0.23)μg/L,P<0.05].sTM>3.2 μg/L환자적주요심장불량사건발생솔현저고우sTM≤3.2 μg/L환자(70.0%비35.7%,P<0.05).결론 sTM수평시반영내피세포손상정도화범위적량호표지,타여관심병위험인자적손상작용유관,병대ACS적병변범위화예후유제시의의.
Objective To study the levels of soluble thrombomodulin (sTM)in patients with acute coronary syndrome (ACS) and evaluate its clinical significance. Method Measured the sTM levels with enzyme linked immunosorbent assay, and described the characteristics of coronary arteriography, risk factors of coronary heart disease, and adverse events in a case-control study of 48 ACS patients (ACS group)and 10 normal people (control group). Results The level of sTM in ACS group was (3.67±1.71) μg/L, and (2.34±0.43)μg/L in control group (P<0.05). The level of sTM in the patients of risk factors or impaired vessels number more than 2 increased significantly than those in the patients of risk factors or impaired vessols number inferior or equal to 2, (4.93±2.76) μg/Lvs (3.13±0.81) μg/L, P<0.05, (4.60± 2.83) μg/L vs (2.91±0.23) μg/L, P < 0.05 respectively. The incidence of cardiac events in the patients of sTM more than 3.2 μg/L (70.0%)was higher significantly than that in the patients of sTM inferior or equal to 3.2 μg/L(35.7%), P< 0.05. Conclusions The levels of sTM are valuable markers to evaluate the impaired degree and scope of endothelial cells in ACS. They are also associated with the number of risk factors, and useful in predicting the extent and prognosis of the disease.
