CAJ | 학술논문

心脏瓣膜生物替代材料发生临床失效的一个主要原因是钙化,其机理非常复杂,涉及一系列决定因素,如含钙细胞外液与膜内磷酸脂反应,形成磷酸钙盐沉积.目前最有效的抗钙化治疗策略有:戊二醛固定组织后加入钙化抑制因子,易钙化位点的剔除或化学修饰,戊二醛固定的改良以及其他化学交联方法.就心脏瓣膜修复材料钙化和抗钙化动物实验研究和临床试验研究进展作一综述.
심장판막생물체대재료발생림상실효적일개주요원인시개화,기궤리비상복잡,섭급일계렬결정인소,여함개세포외액여막내린산지반응,형성린산개염침적.목전최유효적항개화치료책략유:무이철고정조직후가입개화억제인자,역개화위점적척제혹화학수식,무이철고정적개량이급기타화학교련방법.취심장판막수복재료개화화항개화동물실험연구화림상시험연구진전작일종술.
Calcification is a major cause of clinical failure of bioprosthetic and other tissue cardiac valve substitutes.The mechanism of calcification of cardiac valve substitutes is quite complex and has a variety of determinants,involving reaction of calcium-containing extracellular fluid with membrane-associated phosphorus to yield calcium phosphate mineral deposits.The most promising anticalcification strategies have included binding of calcification inhibitors to glutaraldehyde fixed tissue,removal or modification of calcifiable components,modification of glutaraldehyde fixation and use of tissue cross linking agents other than glutaraldehyde.This article reviews current progress toward the research of calcification and anticalcification strategies that are under investigation either in advanced animal models or in clinical trials.