CAJ | 학술논문

目的评价双价肾综合征出血热纯化疫苗(Vero细胞)在6～15岁儿童和>60岁老年人中的免疫原性.方法对知情同意的500名6～15岁(儿童组)、16～60岁(成年人组)和>60岁(老年人组)的健康人群按2∶1∶2的人数比例非随机接种双价肾综合征出血热纯化疫苗(Vero细胞),其中以成年人组作为对照.用ELISA和空斑减少中和试验测定儿童和老年人接种疫苗后的抗体阳转率和几何平均滴度(GMT).结果经ELISA测定,试验组(儿童和老年人)免疫后的抗体阳转率与成年人对照组的差异无统计学意义;老年人组与成年人组的抗体GMT差异无统计学意义,儿童组的GMT水平低于成年人组,差异有统计学意义,但GMT达到有效保护水平.经空斑减少中和试验测定,试验组的抗体阳转率和GMT与对照组的差异均无统计学意义.结论疫苗对≥6岁的所有健康人群接种(禁忌证除外)均具有良好的免疫效果.
목적 평개쌍개신종합정출혈열순화역묘(Vero세포)재6～15세인동화>60세노년인중적면역원성.방법대지정동의적500명6～15세(인동조)、16～60세(성년인조)화>60세(노년인조)적건강인군안2∶1∶2적인수비례비수궤접충쌍개신종합정출혈열순화역묘(Vero세포),기중이성년인조작위대조.용ELISA화공반감소중화시험측정인동화노년인접충역묘후적항체양전솔화궤하평균적도(GMT).결과경ELISA측정,시험조(인동화노년인)면역후적항체양전솔여성년인대조조적차이무통계학의의;노년인조여성년인조적항체GMT차이무통계학의의,인동조적GMT수평저우성년인조,차이유통계학의의,단GMT체도유효보호수평.경공반감소중화시험측정,시험조적항체양전솔화GMT여대조조적차이균무통계학의의.결론역묘대≥6세적소유건강인군접충(금기증제외)균구유량호적면역효과.
Objective To evaluate the immunogenicity of purified bivalent hemorrhagic fever with renal syndrome (HFRS) vaccine (Veto cell) in children (6-15 years) and the elderly (over 60 years). Methods Five hundred healthy people aged 6-15, 16-60, and> 60 were nonrandomly inoculated with tive rate and GMT were determined by ELISA method and plaque reduction neutralization test. Results There were no significant differences of antibody positive rates by ELISA method between the test groups (children and the elderly) and the control. No significant difference of GMT level was found between the elderly group and the control,but the GMT level in children, which was still protective, was significantly lower than that in the control group. There were no significant differences of antibody positive rates and GMT levels by plaque reduction neutralization test between the test groups and the control. Conclusions The purified HFRS vaccine has good immune effect in the healthy people of 6 years and above (with the exception of contraindications).