CAJ | 학술논문

目的通过检测急性缺血性脑卒中患者血浆基质金属蛋白酶-9( matrix metalloproteinase-9,MMP-9)水平变化,探讨其在急性缺血性脑卒中发生发展过程中的作用和意义.方法选择急性缺血性脑卒中患者162例为研究对象,未卒中患者100例作对照,血浆MMP-9检测采用酶联免疫法.结果 (1)急性缺血性脑卒中组血浆MMP-9水平( 193.0±29.3)μ g/L明显高于对照组(82.5±13.7)μg/L,差异有显著性(P＜0.05)；血浆MMP-9浓度与急性缺血性脑卒中的风险成正相关.(2)各型急性缺血性脑卒中血浆MMP-9水平:LAA( 188.3±23.9)μg/L、CE( 197.5±30.2)μg/L、SAA (191.2±32.8)μg/L、SOE( 190.0±0.0)μ g/L、SUE(200.0±23.5)μ g/L,各型间差异均无显著性(F=0.937、P＞0.05).结论 MMP-9是急性缺血性脑卒中的危险标志物；测定MMP-9水平有助于指导预防策略,为急性缺血性脑卒中的预防及临床治疗提供依据.
목적 통과검측급성결혈성뇌졸중환자혈장기질금속단백매-9( matrix metalloproteinase-9,MMP-9)수평변화,탐토기재급성결혈성뇌졸중발생발전과정중적작용화의의.방법 선택급성결혈성뇌졸중환자162례위연구대상,미졸중환자100례작대조,혈장MMP-9검측채용매련면역법.결과 (1)급성결혈성뇌졸중조혈장MMP-9수평( 193.0±29.3)μ g/L명현고우대조조(82.5±13.7)μg/L,차이유현저성(P＜0.05)；혈장MMP-9농도여급성결혈성뇌졸중적풍험성정상관.(2)각형급성결혈성뇌졸중혈장MMP-9수평:LAA( 188.3±23.9)μg/L、CE( 197.5±30.2)μg/L、SAA (191.2±32.8)μg/L、SOE( 190.0±0.0)μ g/L、SUE(200.0±23.5)μ g/L,각형간차이균무현저성(F=0.937、P＞0.05).결론 MMP-9시급성결혈성뇌졸중적위험표지물；측정MMP-9수평유조우지도예방책략,위급성결혈성뇌졸중적예방급림상치료제공의거.
Objective To explore the role and significance of plasma matrix metalloproteinases9 ( MMP-9 )in the genesis and development of acute ischemic stroke by detecting the changes of MMP9 in the patients.Methods 162 patients with acute ischemic stroke were enrolled as research subjects and 100 patients were used as a control.Plasma MMP-9 levels were detected by ELISA.Results MMP-9 level was significantly higher in the stroke group than in the control group [( 193.0 ± 29.3 )μg/L vs.( 82.5 ± 13.7 ) μ g/L,P＜ 0.05].MMP-9 concentration was positively correlated with the risk of acute ischemic stroke.MMP-9 level did not differ significantly among the subtypes of acute ischemic stroke [( 188.3 ± 23.9 ) μ g/L in LAA,( 197.5 ± 30.2 ) μ ug/L in CE,( 191.2 ± 32.8 ) μ g/L in SAA,( 190.0 ± 0.0 ) μ g/L in SOE,and ( 200.0 ± 23.5 ) μ g/L in SUE; P ＞ 0.05].Conclusions MMP-9 is a risk marker of acute ischemic stroke.MMP-9 determination is beneficial in the guidance of prevention strategy for acute ischaemic stroke and provides support for clinical treatment.