中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2009年
6期
581-583
,共3页
柏金秀%杨小巍%孙东明%姬静璐%贾浩%湛要五
柏金秀%楊小巍%孫東明%姬靜璐%賈浩%湛要五
백금수%양소외%손동명%희정로%가호%담요오
新生儿%缺氧缺血性脑病%一氧化氮%白细胞介素-18
新生兒%缺氧缺血性腦病%一氧化氮%白細胞介素-18
신생인%결양결혈성뇌병%일양화담%백세포개소-18
Neonate%Hypoxic ischemic encephalopathy%Nitrogen oxide%Interleukin-18
目的 通过监测新生儿缺氧缺血性脑病(HIE)患儿血清NO、IL-18的变化,探讨NO、IL-18与HIE的相互关系及临床意义.方法 以2007年1月至2007年11月我院收治的HIE新生儿为观察组,正常新生儿为对照组.分别于生后第1、3、7、14天测定HIE组及对照组血清NO和IL-18,分析NO、IL-18的变化及意义.结果 生后第1天,正常对照组血清NO及IL-18含量分别为(6.40±4.24)μmol/L和(2.84±2.53)ng/L;轻度HIE组为(21.55±7.23)μmol/L和(6.79±1.96)ng/L;中度HIE组为(33.38±2.81)μmol/L和(14.07±2.91)ng/L;重度HIE组为(66.39±18.03)μmol/L和(26.85±9.82)ng/L.HIE组血清NO及IL-18含量较对照组均有升高(P均<0.01);且中、重度HIE患儿血清NO及IL-18含量明显高于轻度HIE患儿(P均<0.01).第14天轻、中度HIE组的NO、IL-18含量与对照组对比差异无统计学意义(P均>0.05),而重度HIE组与对照组对比差异有统计学意义[对照组NO及IL-18含量分别为(5.38±4.79)μmol/L和(2.39±1.41)ng/L,重度HIE组分别为(24.86±9.43)μmol/L和(13.43±3.23)ng/L,P均<0.01].方法 NO和IL-18参与HIE的整个发病过程,血清NO及IL-18含量与病情的严重程度有关,可以作为HIE病情变化的监测指标.
目的 通過鑑測新生兒缺氧缺血性腦病(HIE)患兒血清NO、IL-18的變化,探討NO、IL-18與HIE的相互關繫及臨床意義.方法 以2007年1月至2007年11月我院收治的HIE新生兒為觀察組,正常新生兒為對照組.分彆于生後第1、3、7、14天測定HIE組及對照組血清NO和IL-18,分析NO、IL-18的變化及意義.結果 生後第1天,正常對照組血清NO及IL-18含量分彆為(6.40±4.24)μmol/L和(2.84±2.53)ng/L;輕度HIE組為(21.55±7.23)μmol/L和(6.79±1.96)ng/L;中度HIE組為(33.38±2.81)μmol/L和(14.07±2.91)ng/L;重度HIE組為(66.39±18.03)μmol/L和(26.85±9.82)ng/L.HIE組血清NO及IL-18含量較對照組均有升高(P均<0.01);且中、重度HIE患兒血清NO及IL-18含量明顯高于輕度HIE患兒(P均<0.01).第14天輕、中度HIE組的NO、IL-18含量與對照組對比差異無統計學意義(P均>0.05),而重度HIE組與對照組對比差異有統計學意義[對照組NO及IL-18含量分彆為(5.38±4.79)μmol/L和(2.39±1.41)ng/L,重度HIE組分彆為(24.86±9.43)μmol/L和(13.43±3.23)ng/L,P均<0.01].方法 NO和IL-18參與HIE的整箇髮病過程,血清NO及IL-18含量與病情的嚴重程度有關,可以作為HIE病情變化的鑑測指標.
목적 통과감측신생인결양결혈성뇌병(HIE)환인혈청NO、IL-18적변화,탐토NO、IL-18여HIE적상호관계급림상의의.방법 이2007년1월지2007년11월아원수치적HIE신생인위관찰조,정상신생인위대조조.분별우생후제1、3、7、14천측정HIE조급대조조혈청NO화IL-18,분석NO、IL-18적변화급의의.결과 생후제1천,정상대조조혈청NO급IL-18함량분별위(6.40±4.24)μmol/L화(2.84±2.53)ng/L;경도HIE조위(21.55±7.23)μmol/L화(6.79±1.96)ng/L;중도HIE조위(33.38±2.81)μmol/L화(14.07±2.91)ng/L;중도HIE조위(66.39±18.03)μmol/L화(26.85±9.82)ng/L.HIE조혈청NO급IL-18함량교대조조균유승고(P균<0.01);차중、중도HIE환인혈청NO급IL-18함량명현고우경도HIE환인(P균<0.01).제14천경、중도HIE조적NO、IL-18함량여대조조대비차이무통계학의의(P균>0.05),이중도HIE조여대조조대비차이유통계학의의[대조조NO급IL-18함량분별위(5.38±4.79)μmol/L화(2.39±1.41)ng/L,중도HIE조분별위(24.86±9.43)μmol/L화(13.43±3.23)ng/L,P균<0.01].방법 NO화IL-18삼여HIE적정개발병과정,혈청NO급IL-18함량여병정적엄중정도유관,가이작위HIE병정변화적감측지표.
Objective To monitor the levels of NO and IL-18 in neonatal hypoxic-ischemic encephalopathy (HIE), to explore the relation of NO, IL-18 and HIE. Methods HIE infants admitted in our hospital from January to Novermber of 2007 were taken as observation group and normal neonates were chosen as control group. In each group,the concentrations of NO and IL-18 were tested on 1 day,3 days,7 days and 14 days. Results On the first day after birth,the levels of serum NO and IL-18 in control group were (6.40±4.24) μmol/L and (2.84± 2.53)ng/L,in mild HIE group were (21.55±7.23) μmoL/L and (6.79±1.96) ng/L,in moderate HIE group were (33.38±2.81) μmol/L and (14.07±2.91) ng/L,in severe HIE group were (66.39±18.03) μmoL/L and (26.85±9.82) ng/L. The levels of serum NO and IL-18, in HIE groups were higher than those in control group (P<0.01), were much higher in patients with moderate and severe HIE than those with mild HIE (P<0.01). On 14 days,the levels of serum No and IL-18 were not different in moderate HIE groups and those in the control group (P>0.05), butwere higher in the severe HIE groups than those in the control group [NO and IL-8 level: (5.38± 4.79) μmol/L and (2.39±1.41) ng/L in control group and (24.89±9.43) μmol./L and (13.43±3.23) ng/L in severe HIE group(P<0.01)]. Conclusion NO and IL-18 are involved in the whole course of HIE, which are correlated with the severity of condition. They may be acted as indicators in monitoring pationts' conditon.
