中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2008年
22期
12-14
,共3页
垂体腺瘤%侵袭性%组织因子%免疫组织化学
垂體腺瘤%侵襲性%組織因子%免疫組織化學
수체선류%침습성%조직인자%면역조직화학
Pituitary adenoma%Invasive character%Tissue factor%Immunohistochemistry
目的 通过测定垂体腺瘤患者手术切除标本石蜡切片内组织因子(TF)的表达水平以及微血管密度(MVD),进一步探讨其变化与垂体腺瘤侵袭性的关系.方法 采用免疫组化S-P法检测40例垂体腺瘤组织中TF及CD34标记的MVD的表达情况.结果 TF阳性细胞率以及MVD随着肿瘤侵袭性的增高而显著增高,侵袭性组与非侵袭性组的TF表达阳性细胞率之间差异有统计学意义(P<0.01).TF和MVD两者之间呈明显的正相关.结论 TF在侵袭性及非侵袭性垂体腺瘤中均有表达,随着肿瘤侵袭性的增加,TF的表达明显增强,且MVD随TF表达增强而增高,TF可作为侵袭性垂体腺瘤的辅助诊断标准之一.
目的 通過測定垂體腺瘤患者手術切除標本石蠟切片內組織因子(TF)的錶達水平以及微血管密度(MVD),進一步探討其變化與垂體腺瘤侵襲性的關繫.方法 採用免疫組化S-P法檢測40例垂體腺瘤組織中TF及CD34標記的MVD的錶達情況.結果 TF暘性細胞率以及MVD隨著腫瘤侵襲性的增高而顯著增高,侵襲性組與非侵襲性組的TF錶達暘性細胞率之間差異有統計學意義(P<0.01).TF和MVD兩者之間呈明顯的正相關.結論 TF在侵襲性及非侵襲性垂體腺瘤中均有錶達,隨著腫瘤侵襲性的增加,TF的錶達明顯增彊,且MVD隨TF錶達增彊而增高,TF可作為侵襲性垂體腺瘤的輔助診斷標準之一.
목적 통과측정수체선류환자수술절제표본석사절편내조직인자(TF)적표체수평이급미혈관밀도(MVD),진일보탐토기변화여수체선류침습성적관계.방법 채용면역조화S-P법검측40례수체선류조직중TF급CD34표기적MVD적표체정황.결과 TF양성세포솔이급MVD수착종류침습성적증고이현저증고,침습성조여비침습성조적TF표체양성세포솔지간차이유통계학의의(P<0.01).TF화MVD량자지간정명현적정상관.결론 TF재침습성급비침습성수체선류중균유표체,수착종류침습성적증가,TF적표체명현증강,차MVD수TF표체증강이증고,TF가작위침습성수체선류적보조진단표준지일.
Objective To inrestigate the expression of TF and the MVD in the paraffin sections of the pituitary adenomas resected by surgical operation, and investigate the relationship of TF expression and MVD with the invasive character. Methods Expression of TF and CD34 were detected by immunohistochemistry S-P method in 40 cases of pituitary adenoma. Results Positive cell ratio of TF and MVD increase obviously along the invasion increase. There was significant difference between invasive group and non-invasive group(P<0.01). MVD was correlated to the expression of TF. Conclusion Expression of TIe is existed in invasive or non-invasion tissue of pituitary adenoma. Following the increase of pituitary adenoma' s invading character, the positive cell ratio expression of TF and MVD increase obviously. TF can be taken as standard of auxiliary diagnosis for invasive pituitary adenoma.
