肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
2期
134-137
,共4页
罗好曾%米登海%李玉国%苏诚玉
囉好曾%米登海%李玉國%囌誠玉
라호증%미등해%리옥국%소성옥
肝肿瘤%流行病学方法%危险因素%多因子遗传%亚硝胺类%真菌
肝腫瘤%流行病學方法%危險因素%多因子遺傳%亞硝胺類%真菌
간종류%류행병학방법%위험인소%다인자유전%아초알류%진균
Liver neoplasms%Epidemiologc neoplasms%Risk factors%Multifactorial inheritance%Nitrosamines%Fungi
目的 探讨肝癌危险因素在我国西北部肝癌低发区甘肃省武威市的普遍性,给肝癌一级预防提供病因线索.方法 用病例-对照研究方法对武威市居民的肝癌危险因素及家族史进行调查.用简单分离分析方法及Penrose法估计遗传模式,按Falconer回归法计算肝癌遗传度.用培养鉴定及实验检测等手段检测居民膳食中的致(促)癌真菌、挥发性N-亚硝基化合物、饮用水中的硝酸盐、亚硝酸盐、健康成年人血清总维生素C含量.结果 乙肝病史、亲属肿瘤史、食用盐腌食品史、肝硬化病史、饮用地表水与浅井水、饮酒、食用霉变食物等因素是武威市肝癌的危险因素,经分离分析及遗传模式估计,武威市肝癌发病不符合单基因遗传模式,可能为多基因遗传模式.先证者一级亲属的遗传度h~2为58.74%.居民膳食中检出8种亚硝胺,14种致(促)癌真菌.饮用的地表水中硝酸盐氦和亚硝酸盐氮含量分别为(38.97±3.14)mg/L和(0.086±0.043)mg/L;浅井水中硝酸盐氮和亚硝酸盐氮含量分别为(25.88±1.76)mg/L和(0.063±0.032)mg/L.健康成年人夏季血清总维生素c含量为(5.74 4±2.79)mg/L.结论 乙肝病史、家族肿瘤史、食用盐腌食品史、肝硬化、饮用地表水与浅井水、饮酒、食用霉变食物、饮用水中硝酸盐氮和亚硝酸盐氮含量高、膳食中存在挥发性N-亚硝基化合物等多种强致癌物质、缺乏维生索C等防护因素等是武威市居民肝癌发病的危险因素;遗传易感性为导致癌变的内环境.
目的 探討肝癌危險因素在我國西北部肝癌低髮區甘肅省武威市的普遍性,給肝癌一級預防提供病因線索.方法 用病例-對照研究方法對武威市居民的肝癌危險因素及傢族史進行調查.用簡單分離分析方法及Penrose法估計遺傳模式,按Falconer迴歸法計算肝癌遺傳度.用培養鑒定及實驗檢測等手段檢測居民膳食中的緻(促)癌真菌、揮髮性N-亞硝基化閤物、飲用水中的硝痠鹽、亞硝痠鹽、健康成年人血清總維生素C含量.結果 乙肝病史、親屬腫瘤史、食用鹽醃食品史、肝硬化病史、飲用地錶水與淺井水、飲酒、食用黴變食物等因素是武威市肝癌的危險因素,經分離分析及遺傳模式估計,武威市肝癌髮病不符閤單基因遺傳模式,可能為多基因遺傳模式.先證者一級親屬的遺傳度h~2為58.74%.居民膳食中檢齣8種亞硝胺,14種緻(促)癌真菌.飲用的地錶水中硝痠鹽氦和亞硝痠鹽氮含量分彆為(38.97±3.14)mg/L和(0.086±0.043)mg/L;淺井水中硝痠鹽氮和亞硝痠鹽氮含量分彆為(25.88±1.76)mg/L和(0.063±0.032)mg/L.健康成年人夏季血清總維生素c含量為(5.74 4±2.79)mg/L.結論 乙肝病史、傢族腫瘤史、食用鹽醃食品史、肝硬化、飲用地錶水與淺井水、飲酒、食用黴變食物、飲用水中硝痠鹽氮和亞硝痠鹽氮含量高、膳食中存在揮髮性N-亞硝基化閤物等多種彊緻癌物質、缺乏維生索C等防護因素等是武威市居民肝癌髮病的危險因素;遺傳易感性為導緻癌變的內環境.
목적 탐토간암위험인소재아국서북부간암저발구감숙성무위시적보편성,급간암일급예방제공병인선색.방법 용병례-대조연구방법대무위시거민적간암위험인소급가족사진행조사.용간단분리분석방법급Penrose법고계유전모식,안Falconer회귀법계산간암유전도.용배양감정급실험검측등수단검측거민선식중적치(촉)암진균、휘발성N-아초기화합물、음용수중적초산염、아초산염、건강성년인혈청총유생소C함량.결과 을간병사、친속종류사、식용염업식품사、간경화병사、음용지표수여천정수、음주、식용매변식물등인소시무위시간암적위험인소,경분리분석급유전모식고계,무위시간암발병불부합단기인유전모식,가능위다기인유전모식.선증자일급친속적유전도h~2위58.74%.거민선식중검출8충아초알,14충치(촉)암진균.음용적지표수중초산염양화아초산염담함량분별위(38.97±3.14)mg/L화(0.086±0.043)mg/L;천정수중초산염담화아초산염담함량분별위(25.88±1.76)mg/L화(0.063±0.032)mg/L.건강성년인하계혈청총유생소c함량위(5.74 4±2.79)mg/L.결론 을간병사、가족종류사、식용염업식품사、간경화、음용지표수여천정수、음주、식용매변식물、음용수중초산염담화아초산염담함량고、선식중존재휘발성N-아초기화합물등다충강치암물질、결핍유생색C등방호인소등시무위시거민간암발병적위험인소;유전역감성위도치암변적내배경.
Objective To investigate the widespread of the liver cancer risk factors in Wuwei city,where low-incidence for liver cancer and offer the cause clue to first-level prevention. Methods Investigate the risk factor and family history of the Wuwei city resident who wlth liver cancer by using case-control study.Estimate the liver cancer heredity mode with the method of Penrose and simple segregation analysis,calculate the degree of heritability with the metllod of Falconer,s regression.Detect the content of the resulting and promoting cancer fungi,volatility N-second nitroso compound in the meal,nitrate and nitrite in the drinking water and the vitamin C in the health adults'serum by means of culturing appraisement,experiment examination etc.Results The risk factom of liver cancer in the Wuwei city were history of viral 'hepatitis type B,kinsfolk tumor,the eating salting or mildewed foods,cirrhosis,drinking surface water,well water,or wine.By using segregation analysis and estimation of heredity mode show that the morbidity of liver cancer discrepancy to the monogenic inheritance mode,maybe the polygenic inheritance mode in Wuwei city.The h~2 of index case first degree relative was 58.74%.Picking out 8 kinds of nitrosamine,14 kinds of resulting and promoting cancer fungi from resident meal.The content of nitrate and nitrite was (38.97±3.14) mg/L,(0.086±0.043) mg/L respectively in shallow well water,the vitamin C in the health adults'serum in summer was(5.74±2.79)mg/L.Conclusion It can be seen that the history of viral hepatitis type B,kinsfolk tumor,eating salting or mildewed foods,cirrhosis,addicted to drink;higher content of nitrate and nitrite in the drinking water and strong carcinogens such as volatility N-nitroso compound in the meal,and also lackingprotection factors such as vitamin C are the risk factors of the Wuwei city resident who with liver cancer,Theinherit susceptivity is the internal environment of resulting cancer change.
