CAJ | 학술논문

目的探讨肺癌和慢性阻塞性肺疾病(COPD)患者中肺炎衣原体(Cpn)的感染状况.方法应用固相酶联免疫吸附法,对确诊的128例肺癌和126例COPD急性加重期患者进行血清肺炎衣原体抗体IgM,IgG检测,以70例健康人为正常对照组(简称对照组).结果COPD组肺炎衣原体IgM抗体阳性率(36.5%,46/126)及IgM和/或IgG阳性率(32.8%,42/126),均较肺癌组(分别为21.8%,28/128和23.1%,30/128)及对照组(分别为1.4%,1/70和2.8%,2/70)明显升高(P＜0.005),肺癌组IgM阳性率较对照组明显升高(P＜0.005)IgM和/或IgG阳性人数为74例,总感染率为22.8%(74/324).结论肺癌和COPD患者都是Cpn易感染人群,其Cpn感染主要表现为急性感染.Cpn可能是COPD急性加重和肺癌合并肺部感染的主要病原.
목적탐토폐암화만성조새성폐질병(COPD)환자중폐염의원체(Cpn)적감염상황.방법응용고상매련면역흡부법,대학진적128례폐암화126례COPD급성가중기환자진행혈청폐염의원체항체IgM,IgG검측,이70례건강인위정상대조조(간칭대조조).결과COPD조폐염의원체IgM항체양성솔(36.5%,46/126)급IgM화/혹IgG양성솔(32.8%,42/126),균교폐암조(분별위21.8%,28/128화23.1%,30/128)급대조조(분별위1.4%,1/70화2.8%,2/70)명현승고(P＜0.005),폐암조IgM양성솔교대조조명현승고(P＜0.005)IgM화/혹IgG양성인수위74례,총감염솔위22.8%(74/324).결론폐암화COPD환자도시Cpn역감염인군,기Cpn감염주요표현위급성감염.Cpn가능시COPD급성가중화폐암합병폐부감염적주요병원.
Objective: To investigate the presence of chlamydia pneumoniae (Cpn) infection in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and lung cancer. Methods: Serum IgM and IgG antibodies for Chlamydia pneumoniae in patients, in which 126 and 128 cases were COPD and lung cancer group respectively, were measured by enzyme-linked immunosorbant assays. The 70 samples of the healthy control group were selected from the healthy outpatients during physical examinations. Results:The positive ratio of serologic IgM antibodies for Cpn in group COPD was up to 36.5% (46/126) which was much higher than that in group lung cancer (21.8%, 28/128) and that in the control (1.4%, 1/70). The difference was statistically significant (P ＜0.005), respectively . And the ratio of group lung cancer was the same statistically significant difference (P ＜0.005). While the positive ratio of serologic IgG antibodies in either group COPD or group lung cancer was no statistical significance, compared with the control. But the positive ratio of IgM and /or IgG antibodies of group COPD and group lung cancer were 32.8% (42/126) and 23.1%(30/128), respectively. which had the significant differences, compared with the control. And the total-positive ratio of all the samples reached 22.8% (74/324). Conclusion: It shows that patients with lung cancer accompanied by pulmonary infection and acute exacerbation of chronic obstructive pulmonary disease are all liable to the infection of chlamydia pneumoniae, of which the clinical presentation is acute infection. And Cpn may be the main pathogenic microbes of those patients and so Cpn infection should be considered for patients with lung cancer companied with pulmonary infection and acute exacerbation of COPD.