农药学学报
農藥學學報
농약학학보
CHINESE JOURNAL OF PESTICIDE SCIENCE
2005年
1期
73-76
,共4页
翁建全%沈德隆%陈杰%刘会君%陈庆悟%谭成侠
翁建全%瀋德隆%陳傑%劉會君%陳慶悟%譚成俠
옹건전%침덕륭%진걸%류회군%진경오%담성협
N-烃氧羰基-2-噻唑烷酮衍生物%合成%杀菌活性
N-烴氧羰基-2-噻唑烷酮衍生物%閤成%殺菌活性
N-경양탄기-2-새서완동연생물%합성%살균활성
N-Carboalkoxy(aryloxy)-2-thiazolidinones%synthesis%fungicidal activity
为了寻求新的杀菌先导化合物,通过2-噻唑烷酮与氯甲酸酯的缩合反应得到11个N-烃氧羰基-2-噻唑烷酮衍生物(5a ～5k),其中10个为新化合物,其结构均经1H NMR、MS、IR和元素分析表征.初步离体杀菌实验结果表明,大多数化合物较之母体2-噻唑烷酮具有更高的杀菌活性.在浓度为2 000 mg/L下,化合物5c、5d、5e、5f、5g、5h、5i、5j对油菜菌核病菌Sclerotinia sclerotiorum的抑制率为100%,5i对番茄灰霉病菌Botrytis cinerea、柑桔青霉病菌Penicillium italicum和油菜菌核病菌的抑制率均为100%.
為瞭尋求新的殺菌先導化閤物,通過2-噻唑烷酮與氯甲痠酯的縮閤反應得到11箇N-烴氧羰基-2-噻唑烷酮衍生物(5a ～5k),其中10箇為新化閤物,其結構均經1H NMR、MS、IR和元素分析錶徵.初步離體殺菌實驗結果錶明,大多數化閤物較之母體2-噻唑烷酮具有更高的殺菌活性.在濃度為2 000 mg/L下,化閤物5c、5d、5e、5f、5g、5h、5i、5j對油菜菌覈病菌Sclerotinia sclerotiorum的抑製率為100%,5i對番茄灰黴病菌Botrytis cinerea、柑桔青黴病菌Penicillium italicum和油菜菌覈病菌的抑製率均為100%.
위료심구신적살균선도화합물,통과2-새서완동여록갑산지적축합반응득도11개N-경양탄기-2-새서완동연생물(5a ～5k),기중10개위신화합물,기결구균경1H NMR、MS、IR화원소분석표정.초보리체살균실험결과표명,대다수화합물교지모체2-새서완동구유경고적살균활성.재농도위2 000 mg/L하,화합물5c、5d、5e、5f、5g、5h、5i、5j대유채균핵병균Sclerotinia sclerotiorum적억제솔위100%,5i대번가회매병균Botrytis cinerea、감길청매병균Penicillium italicum화유채균핵병균적억제솔균위100%.
In order to find new fungicidal lead compounds,eleven N-carboalkoxy(aryloxy)-2-thiazolidinones, ten of which are novel compounds, were prepared from a condensation reaction of 2-thiazolidinone and chloroformate, and their structures were confirmed by 1H NMR, MS, IR and elemental analysis. The results of fungicidal tests, at the concentration of 2 000mg/L, indicated that some of them exhibited good activities toward various plant disease fungi. Compounds 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j showed excellent inhibitory activities (100%) against Sclerotinia sclerotiorum. Compound 5i showed excellent inhibitory activities (100%) against Botrytis cinerea, Penicillium italicum and S.sclerotiorum, and also showed inhibitory activities against Xanthomonas oryzae, Pseudomonas solanacearum.
