世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
WORLD JOURNAL OF TRADITIONAL CHINESE AND WESTERN MEDICINE
2009年
7期
467-469,472
,共4页
枳术饮%功能性消化不良%肠道动力%乙酰胆碱酯酶%胃动素
枳術飲%功能性消化不良%腸道動力%乙酰膽堿酯酶%胃動素
지술음%공능성소화불량%장도동력%을선담감지매%위동소
Zhi Zhu Yin%Functional dyspepsia%Intestinal motility%Acetylcholine esterase%Motilin
目的 探讨枳术饮对功能性消化不良(FD)大鼠肠道动力的影响.方法 将Wistar大鼠随机分为正常对照组、模型对照组、枳术饮组和西沙比利组,每组10只.复制大鼠胃电节律失常模型,药物干预后分别以葡聚糖蓝-2000为胃肠内标记物,观察大鼠肠道传输速率的变化及十二指肠病理组织学改变.免疫组织化学法观察十二指肠组织乙酰胆碱酯酶(AchE)、胃动素(MTL)阳性神经分布的变化.结果 模型对照组大鼠肠道传输速率显著降低(P＜0.01),十二指肠组织AchE 、MTL阳性神经分布显著减少(P＜0.01).枳术饮可明显促进模型大鼠肠道传输速率(P＜0.01),明显增加十二指肠组织AchE、MTL阳性神经分布(P＜0.05,P＜0.01).结论 枳术饮能够改善FD大鼠肠动力障碍,其作用机制可能与十二指肠AchE、MTL阳性神经分布增加有关.
目的 探討枳術飲對功能性消化不良(FD)大鼠腸道動力的影響.方法 將Wistar大鼠隨機分為正常對照組、模型對照組、枳術飲組和西沙比利組,每組10隻.複製大鼠胃電節律失常模型,藥物榦預後分彆以葡聚糖藍-2000為胃腸內標記物,觀察大鼠腸道傳輸速率的變化及十二指腸病理組織學改變.免疫組織化學法觀察十二指腸組織乙酰膽堿酯酶(AchE)、胃動素(MTL)暘性神經分佈的變化.結果 模型對照組大鼠腸道傳輸速率顯著降低(P＜0.01),十二指腸組織AchE 、MTL暘性神經分佈顯著減少(P＜0.01).枳術飲可明顯促進模型大鼠腸道傳輸速率(P＜0.01),明顯增加十二指腸組織AchE、MTL暘性神經分佈(P＜0.05,P＜0.01).結論 枳術飲能夠改善FD大鼠腸動力障礙,其作用機製可能與十二指腸AchE、MTL暘性神經分佈增加有關.
목적 탐토지술음대공능성소화불량(FD)대서장도동력적영향.방법 장Wistar대서수궤분위정상대조조、모형대조조、지술음조화서사비리조,매조10지.복제대서위전절률실상모형,약물간예후분별이포취당람-2000위위장내표기물,관찰대서장도전수속솔적변화급십이지장병리조직학개변.면역조직화학법관찰십이지장조직을선담감지매(AchE)、위동소(MTL)양성신경분포적변화.결과 모형대조조대서장도전수속솔현저강저(P＜0.01),십이지장조직AchE 、MTL양성신경분포현저감소(P＜0.01).지술음가명현촉진모형대서장도전수속솔(P＜0.01),명현증가십이지장조직AchE、MTL양성신경분포(P＜0.05,P＜0.01).결론 지술음능구개선FD대서장동력장애,기작용궤제가능여십이지장AchE、MTL양성신경분포증가유관.
Objective To investigate the effect of Zhi Zhu Yin on intestinal motility in rats with functional dyspepsia(FD)and its mechanism.Methods Wistar rats were randomized into normal group,model group,Zhi Zhu Yin group and cisapride group,10 rats in each one.Gastroelectric dysrhythmias model was duplicated in rats.After drug intervention,dextran blue-2000 was used as gastrointestinal marker to observe the changes of gastrointestinal transit rate and pathohistological changes of duodenum.The immunohistochemic method was used to observe the changes of distribution of duodenal acetylcholine esterase(AchE)and motilin(MTL)positive nerves.Results In model group,the gastrointestinal transit rate reduced significantly in rats(P＜0.01),the distributions of AchE and MTL positive nerves decreased in duodenal tissue significantly(P＜0.01).Zhi Zhu Yin promoted the gastrointestinal transit rate apparently in modeled rats(P＜0.01)and increased significantly the distributions of AchE and MTL positive nerves in duodenal tissue(P＜0.05,P＜0.01).Conclusion Zhi Zhu Yin can improve intestinal motility of rats with functional dyspepsia,which may be related to the increased distributions of AchE and MTL positive nerves in duodenum.
