CAJ | 학술논문

目的评价口服乾坤宁治疗甲型H1N1流感病例的疗效. 方法回顾性分析227例接受乾坤宁、达菲、乾坤宁合用达菲或单纯对症治疗的甲型H1N1流感病例的疗效. 结果根据入选标准和排除标准共人选112例,其中达菲治疗组仅4例,不予统计学分析.实际纳入分析共108例.使用乾坤宁治疗后,甲型H1N1流感8个主要症状持续时间之和的中位天数为6d,短于对症治疗组的7.5d(P<0.05).乾坤宁+达菲治疗后流感病毒核酸转阴最快,中位天数为2d,乾坤宁组为3d,无显著性差异(P=0.054);但两组均显著快于对症治疗组的4d(P<0.001,P=0.025).乾坤宁开始治疗1d后,症状缓解相对较快,23.3%的病例(7/30)症状可完全缓解,而对症治疗组为12%(6/50),但无显著性差异(P>0.05);治疗3d后,70.4%病例(76/108)症状完全缓解,各组问结果类似. 结论中药乾坤宁治疗甲型H1N1流感病例,具有抗病毒,缓解症状,快速退热和缩短病程的作用,且无明显不良反应.
목적 평개구복건곤저치료갑형H1N1류감병례적료효. 방법 회고성분석227례접수건곤저、체비、건곤저합용체비혹단순대증치료적갑형H1N1류감병례적료효. 결과 근거입선표준화배제표준공인선112례,기중체비치료조부4례,불여통계학분석.실제납입분석공108례.사용건곤저치료후,갑형H1N1류감8개주요증상지속시간지화적중위천수위6d,단우대증치료조적7.5d(P<0.05).건곤저+체비치료후류감병독핵산전음최쾌,중위천수위2d,건곤저조위3d,무현저성차이(P=0.054);단량조균현저쾌우대증치료조적4d(P<0.001,P=0.025).건곤저개시치료1d후,증상완해상대교쾌,23.3%적병례(7/30)증상가완전완해,이대증치료조위12%(6/50),단무현저성차이(P>0.05);치료3d후,70.4%병례(76/108)증상완전완해,각조문결과유사. 결론 중약건곤저치료갑형H1N1류감병례,구유항병독,완해증상,쾌속퇴열화축단병정적작용,차무명현불량반응.
Objective To evaluate the efficacy of therapy with oral Qiankunning for patients with H1N1-A Influenza infection. Methods 108 patients with H1N1-A Influenza infection were recruited and divided into three groups by different therapy:treatment with Qiankunning,combination therapy with Qiankunning and Oseltamivir,and symptomatic treatment.A retrospective study was performed to evaluate the efficacy of these three treatments. Results The median of duration of 8 symptoms in patients with Qiankunning therapy (6,ranged from 2 to 40) and combination therapy (6,ranged from 1 to 21) were significantly shorter than that in patients with symptomatic treatment (7.5,ranged from 1 to 25),(P <0.05).The median of virus shedding were 2 days (from 1 to 4) in patients using combination therapy with Qiankunning and Oseltamivir and 3 days (1-5days) in patients treated with Qiankunning,shorter that that in patients with symptomatic treatment (4 days,from 2 to 7days),(P<0.001,P = 0.025,respectively).The frequency of symptoms remission in the patients with Qiankunning therapy was 23.3% (7/30) after 1 day therapy,better than that in patients with symptomatic treatment (12%,6/50),and after 3 days therapy,70.4% (76/108) of patients gained remission in three groups and there was no difference amongst these groups. Conclusions Qiankunning plays an important role in the control of H1N1-A Influenza infection,especially in the control of viral replication,remission of symptoms,lower the temperature and shorter disease progression,and there is no adverse effect found during the therapy.