CAJ | 학술논문

采用红外光谱法(FTIR)、二阶导数红外光谱法和二维相关光谱分析技术(Two-dimensional correlation spectroscopy)研究不同配伍方式的大血藤、牡丹皮、赤芍水煎液的"宏观指纹特征".结果表明,不同配伍方式的复方水煎液在3种谱图上均具有显著的变化规律.君药大血藤的特征峰1 610,1 518,1 446 cm~(-1)为芳香物的特征峰,说明大血藤提取物中含有大最芳香类化合物,说明君药在原配伍中具有很好的溶出度,有效成分得以充分利用.不同比例的水煎剂中1 614 cm~(-1)的特征峰倾向于大血藤1 610 cm~(-1),说明大血藤对水煎剂溶出物质影响较大.根据对特征峰的指认和归属,可揭爪药物剂量的增减对复方整体配伍的影响.所提方法为中药复方配伍整体研究提供了新的途径.
채용홍외광보법(FTIR)、이계도수홍외광보법화이유상관광보분석기술(Two-dimensional correlation spectroscopy)연구불동배오방식적대혈등、모단피、적작수전액적"굉관지문특정".결과표명,불동배오방식적복방수전액재3충보도상균구유현저적변화규률.군약대혈등적특정봉1 610,1 518,1 446 cm~(-1)위방향물적특정봉,설명대혈등제취물중함유대최방향류화합물,설명군약재원배오중구유흔호적용출도,유효성분득이충분이용.불동비례적수전제중1 614 cm~(-1)적특정봉경향우대혈등1 610 cm~(-1),설명대혈등대수전제용출물질영향교대.근거대특정봉적지인화귀속,가게조약물제량적증감대복방정체배오적영향.소제방법위중약복방배오정체연구제공료신적도경.
Fourier transform spectroscopy (FTIR) and two-dimensional correlation spectroscopy were used to analyze different compatibility forms of sargentgloryvine stem,radix paeoniae rubra and cortex moutan in order to study the FTIR spectra of different proportion formulas.The results indicate that different proportion formulas have distinct change regularity in FTIR spectra,second derivative spectra and synchronous 2D.Key components of sargentgloryvine stem's characteristic absorption band are 1 610,1 518 and 1 446 cm~(-1) which are characteristic absorption band of aromatic material,and in the original formula,that shows stronger peak than others,suggesting that original formula can make the best of composition of drug action.In the different proportion formulas,1 614 cm~(-1) is nearer to 1 610 cm~(-1),which is sargentgloryvine stem's characteristic absorption band,than to 1 706 cm~(-1),illustrating that sargentgloryvine stem is more influential formula than others.According to identification and ascription of characteristic absorption band,it was initially revealed that different proportion of drug dosage can affect pharmacodynamic action of integral formula.