国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2010年
3期
176-179
,共4页
李永平%王立明%郭志荣%廖福龙
李永平%王立明%郭誌榮%廖福龍
리영평%왕립명%곽지영%료복룡
血液流变学%模型%血浆%三七%参数
血液流變學%模型%血漿%三七%參數
혈액류변학%모형%혈장%삼칠%삼수
Hemorheology%Model%Plasma%Notoginseng saponin%Parameter
目的 有人用旋转黏度计在恒定的低切变率下测定了抗凝血样复钙后的切应力随时间变化的曲线.笔者针对这一方法提出了一种凝血过程的血液流变学理论模型,本研究试图寻求并分析2种大鼠血浆(正常血浆、富血小板血浆)在给予三七皂苷前后其各自模型参数的差异.方法 应用模型拟合实验数据,比较所得2种大鼠血浆给予三七皂苷前后其各自的模型参数,从中找出差异.结果 模型参数中的大部分没有变化,只有少数几个参数发生变化,有的甚至变化很大.结论 模型拟合出的各种模型参数均有明确的血液流变学意义,通过模型参数的变化可以分析出血浆受药物影响前后其凝固性能的差异.
目的 有人用鏇轉黏度計在恆定的低切變率下測定瞭抗凝血樣複鈣後的切應力隨時間變化的麯線.筆者針對這一方法提齣瞭一種凝血過程的血液流變學理論模型,本研究試圖尋求併分析2種大鼠血漿(正常血漿、富血小闆血漿)在給予三七皂苷前後其各自模型參數的差異.方法 應用模型擬閤實驗數據,比較所得2種大鼠血漿給予三七皂苷前後其各自的模型參數,從中找齣差異.結果 模型參數中的大部分沒有變化,隻有少數幾箇參數髮生變化,有的甚至變化很大.結論 模型擬閤齣的各種模型參數均有明確的血液流變學意義,通過模型參數的變化可以分析齣血漿受藥物影響前後其凝固性能的差異.
목적 유인용선전점도계재항정적저절변솔하측정료항응혈양복개후적절응력수시간변화적곡선.필자침대저일방법제출료일충응혈과정적혈액류변학이론모형,본연구시도심구병분석2충대서혈장(정상혈장、부혈소판혈장)재급여삼칠조감전후기각자모형삼수적차이.방법 응용모형의합실험수거,비교소득2충대서혈장급여삼칠조감전후기각자적모형삼수,종중조출차이.결과 모형삼수중적대부분몰유변화,지유소수궤개삼수발생변화,유적심지변화흔대.결론 모형의합출적각충모형삼수균유명학적혈액류변학의의,통과모형삼수적변화가이분석출혈장수약물영향전후기응고성능적차이.
Objective An experimental approach was proposed to measure the shear stress change over time(curve) of an anti-coagulative blood sample after recalcification under a constant shear rate in a rotational vis-cometer and a hemorheological model was established based on this approach. In this paper, the effects of notoginseng saponin on the hemorhelogical model parameters of normal rat plasma and platelet-rich rat plasma were investigated. Methods The hemorheological model was introduced to fit the experimental data and the changes in hemorhelogical model parameters of two kinds of rat plasma before and after the addition of notoginseng saponin were investigated. Results Most of the parameters of the theoretic model did not change, while only a few of parameters changed, and of which several significant change happened. Conclusion The experimental results indicate that the fitted model parameters have clear meaning of hemorheology, and the model parameters can be used for evaluating the influence of a drug on plasma clotting.
