国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2008年
5期
318-321
,共4页
骨髓间充质干细胞%免疫调节%免疫抑制
骨髓間充質榦細胞%免疫調節%免疫抑製
골수간충질간세포%면역조절%면역억제
mesenchymal stem cell%immunological regulation%immune suppression
间充质干细胞是除造血干细胞以外的一种成体干细胞,具有自我更新、横向分化和免疫调节作用.间充质干细胞本身具有低免疫原性;在体外试验中表现出免疫抑制的作用,具有诱导免疫耐受的功能.间充质干细胞抑制T细胞对同种抗原和分裂素刺激的增生,阻碍细胞毒性T淋巴细胞细胞的发育;另外对抗原呈递细胞、自然杀伤细胞、B细胞等淋巴细胞都有相应的影响.
間充質榦細胞是除造血榦細胞以外的一種成體榦細胞,具有自我更新、橫嚮分化和免疫調節作用.間充質榦細胞本身具有低免疫原性;在體外試驗中錶現齣免疫抑製的作用,具有誘導免疫耐受的功能.間充質榦細胞抑製T細胞對同種抗原和分裂素刺激的增生,阻礙細胞毒性T淋巴細胞細胞的髮育;另外對抗原呈遞細胞、自然殺傷細胞、B細胞等淋巴細胞都有相應的影響.
간충질간세포시제조혈간세포이외적일충성체간세포,구유자아경신、횡향분화화면역조절작용.간충질간세포본신구유저면역원성;재체외시험중표현출면역억제적작용,구유유도면역내수적공능.간충질간세포억제T세포대동충항원화분렬소자격적증생,조애세포독성T림파세포세포적발육;령외대항원정체세포、자연살상세포、B세포등림파세포도유상응적영향.
Besides the haemopoietic stem cell, mesenchymal stem cell (MSC) is an adult stem cell in the marrow. It has the ability to self-renew, differentiate into various kinds of tissue and regulate the immunological system. MSC possess low immunogenicity. It shows the immunosuppressive ability in vitro and has function of inducing immune-tolerance. MSC suppress accrementition of T cell respone to the allotigen and mitogen and hinderes the development of cytotoxic T lymphocyte cell. In addition, MSC can influence antigen presenting cell, natural kill cell, B cell, and so on.
