CAJ | 학술논문

胰岛素抵抗和高血糖谷氨酸钠(MSG)小鼠的血胰岛素水平均明显升高(P<0.01),胰腺重量指数降低(P<0.01),胰腺外分泌组织都出现不同程度的炎性浸润,并且胰岛内胰岛素和胰升糖素的分布发生变化,含量也明显增加(P<0.01).与胰岛素抵抗MSC小鼠相比,高血糖MSG小鼠血胰岛素水平却明显降低(P<0.05),胰腺重量下降(P<0.05);胰岛数量减少,体积缩小,胰岛内胰岛素含量降低(P<0.01),胰升糖素含量增加(P<0.05),提示其胰腺损伤更加严重,这可能是引起其血糖升高的主要原因.
이도소저항화고혈당곡안산납(MSG)소서적혈이도소수평균명현승고(P<0.01),이선중량지수강저(P<0.01),이선외분비조직도출현불동정도적염성침윤,병차이도내이도소화이승당소적분포발생변화,함량야명현증가(P<0.01).여이도소저항MSC소서상비,고혈당MSG소서혈이도소수평각명현강저(P<0.05),이선중량하강(P<0.05);이도수량감소,체적축소,이도내이도소함량강저(P<0.01),이승당소함량증가(P<0.05),제시기이선손상경가엄중,저가능시인기기혈당승고적주요원인.
The blood insulin levels of insulin resistant monosodium glutamate induced mice (IR-MSG)and hyperglycemic monosodium glutamate mice (HG-MSG) markedly increased ( P<0. 01 ), and the weight index of pancreas significantly decreased ( P<0. 01 ), accompanied with overt inflammatory infiltration in the exocrine part of pancreas. Besides, insulin and glucagon in the islets also markedly increased with irregular distribution ( P<0.01 ). Compared to IR-MSG mice, HG-MSG mice showed overt hyperglycemia and much lower blood insulin. Moreover, the weight of pancreas in HG-MSG mice markedly decreased ( P < 0.05 ), along with less insulin and more glucagon in the lessened and contracted islets, suggesting that the injury of pancreas in the HGMSG mice might be more severe, which may result in hyperglycemia.