中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2012年
8期
799-802
,共4页
杜辉%吴瑞芳%汤惠茹%乌兰娜%张礼婕%刘志红%李鹃%李瑞珍%王国萍%周艳秋%王纯%翁雷明
杜輝%吳瑞芳%湯惠茹%烏蘭娜%張禮婕%劉誌紅%李鵑%李瑞珍%王國萍%週豔鞦%王純%翁雷明
두휘%오서방%탕혜여%오란나%장례첩%류지홍%리견%리서진%왕국평%주염추%왕순%옹뢰명
宫颈肿瘤%人乳头瘤病毒%宫颈上皮内瘤样病变
宮頸腫瘤%人乳頭瘤病毒%宮頸上皮內瘤樣病變
궁경종류%인유두류병독%궁경상피내류양병변
Cervical neoplasms%Human papillomavirus%Cervical intraepithelial lesion
目的 了解深圳市成年女性生殖道高危型人乳头瘤病毒(HPV)感染与宫颈癌患病情况.方法 2006年4月至2010年4月采取整群抽样方法,对深圳市罗湖、福田、南山、龙岗和保安区20 ～ 59岁有性生活史的女性开展宫颈癌筛查.受筛查妇女均行宫颈脱落细胞液基细胞学检查(LCT)或者新柏氏液基细胞学检查(TCT)和第二代杂交捕获技术(HC-Ⅱ).对HPV阳性,且细胞学≥未明确诊断意义的不典型鳞状上皮细胞( ASC-US)和/或LCT/TCT≥低度鳞状上皮内瘤样病变(LSIL)的妇女均行阴道镜下活组织病理检查,以确定有无宫颈上皮内瘤样病变(CIN)或宫颈癌.结果 共筛查10 210名妇女,其中10 017人检验结果完整,高危型HPV-DNA的总检出率为16.29％,其中20～、30～、35～、40～、45～和50～59岁组的检出率分别为17.37％、15.59％、16.33％、14.74％、17.16％和17.98％.年龄别HPV感染率曲线呈“W”形.25～和50 ～ 59岁组HPV感染率明显高于其他各年龄组( x2=4.50,P=0.03)；CIN Ⅰ、CINⅡ/Ⅲ、宫颈癌的现患率分别为5.32％、2.21％和0.12％,CIN Ⅰ明显高于CINⅡ/Ⅲ(x2=134.15,P＜0.001),45～岁组宫颈癌现患率最高,为0.12％.深圳市各区HPV感染差异有统计学意义(x2=17.81,P=0.03),其中福田区和罗湖区HPV感染率高于南山、宝安和龙岗区；宝安区CIN现患率最低,其他各区CIN现患率间的差异无统计学意义(x2=4.84,P=0.18).结论 深圳市成年女性宫颈癌患病率较低,宫颈病变多处于发病早期,重点应预防HPV感染和治疗CIN.
目的 瞭解深圳市成年女性生殖道高危型人乳頭瘤病毒(HPV)感染與宮頸癌患病情況.方法 2006年4月至2010年4月採取整群抽樣方法,對深圳市囉湖、福田、南山、龍崗和保安區20 ～ 59歲有性生活史的女性開展宮頸癌篩查.受篩查婦女均行宮頸脫落細胞液基細胞學檢查(LCT)或者新柏氏液基細胞學檢查(TCT)和第二代雜交捕穫技術(HC-Ⅱ).對HPV暘性,且細胞學≥未明確診斷意義的不典型鱗狀上皮細胞( ASC-US)和/或LCT/TCT≥低度鱗狀上皮內瘤樣病變(LSIL)的婦女均行陰道鏡下活組織病理檢查,以確定有無宮頸上皮內瘤樣病變(CIN)或宮頸癌.結果 共篩查10 210名婦女,其中10 017人檢驗結果完整,高危型HPV-DNA的總檢齣率為16.29％,其中20～、30～、35～、40～、45～和50～59歲組的檢齣率分彆為17.37％、15.59％、16.33％、14.74％、17.16％和17.98％.年齡彆HPV感染率麯線呈“W”形.25～和50 ～ 59歲組HPV感染率明顯高于其他各年齡組( x2=4.50,P=0.03)；CIN Ⅰ、CINⅡ/Ⅲ、宮頸癌的現患率分彆為5.32％、2.21％和0.12％,CIN Ⅰ明顯高于CINⅡ/Ⅲ(x2=134.15,P＜0.001),45～歲組宮頸癌現患率最高,為0.12％.深圳市各區HPV感染差異有統計學意義(x2=17.81,P=0.03),其中福田區和囉湖區HPV感染率高于南山、寶安和龍崗區；寶安區CIN現患率最低,其他各區CIN現患率間的差異無統計學意義(x2=4.84,P=0.18).結論 深圳市成年女性宮頸癌患病率較低,宮頸病變多處于髮病早期,重點應預防HPV感染和治療CIN.
목적 료해심수시성년녀성생식도고위형인유두류병독(HPV)감염여궁경암환병정황.방법 2006년4월지2010년4월채취정군추양방법,대심수시라호、복전、남산、룡강화보안구20 ～ 59세유성생활사적녀성개전궁경암사사.수사사부녀균행궁경탈락세포액기세포학검사(LCT)혹자신백씨액기세포학검사(TCT)화제이대잡교포획기술(HC-Ⅱ).대HPV양성,차세포학≥미명학진단의의적불전형린상상피세포( ASC-US)화/혹LCT/TCT≥저도린상상피내류양병변(LSIL)적부녀균행음도경하활조직병리검사,이학정유무궁경상피내류양병변(CIN)혹궁경암.결과 공사사10 210명부녀,기중10 017인검험결과완정,고위형HPV-DNA적총검출솔위16.29％,기중20～、30～、35～、40～、45～화50～59세조적검출솔분별위17.37％、15.59％、16.33％、14.74％、17.16％화17.98％.년령별HPV감염솔곡선정“W”형.25～화50 ～ 59세조HPV감염솔명현고우기타각년령조( x2=4.50,P=0.03)；CIN Ⅰ、CINⅡ/Ⅲ、궁경암적현환솔분별위5.32％、2.21％화0.12％,CIN Ⅰ명현고우CINⅡ/Ⅲ(x2=134.15,P＜0.001),45～세조궁경암현환솔최고,위0.12％.심수시각구HPV감염차이유통계학의의(x2=17.81,P=0.03),기중복전구화라호구HPV감염솔고우남산、보안화룡강구；보안구CIN현환솔최저,기타각구CIN현환솔간적차이무통계학의의(x2=4.84,P=0.18).결론 심수시성년녀성궁경암환병솔교저,궁경병변다처우발병조기,중점응예방HPV감염화치료CIN.
Objective To investigate the prevalence of high risk human papillomavirus (HPV) genital infection and cervical cancer in adult women from Shenzhen.Methods Cluster sampling was used to investigate the prevalence of HPV infection and cervical cancer from women aged 20-59 years old living in Luohu,Futian,Nanshan,Longgang and Baoan districts in Shenzhen from April 2006 to April 2010.All women were detected for liquid-based cytology test (LCT) or Thinprep cytologic test (TCT)and high-risk HPV-DNA test with hybrid capture Ⅱ (HC-Ⅱ ).All women with ≥ASC-US by cytology and/or a positive HC- Ⅱ test were asked to return for colposcopy and four-quadrant biopsy.Endocervical curettage was performed.Pathological finding were used as the gold standard of the diagnosis of cervical intraepithelial neoplasia.Results 10 210 women were involved in the study and 10 017 of them having completed data.The overall positive rate of high-risk HPV-DNA was 16.29％.HPV positive rates in 20-,30-,35-,40-,45-,50-59 age groups were 17.37％,15.59％,16.33％,14.74％,17.16％ and 17.98％,respectively.The curve of HPV infection rates in different age groups appeared a ‘W' shape.HPV infection rates in the 25-years-olds and 50-59 year-olds groups were significantly higher than the other age groups (x2=4.50,P=0.03 ).The overall prevalence rate of cervical intraepithelial lesions (CIN) was 7.52％,of which the prevalence rates of low-grade cervical intraepithelial lesions (CIN Ⅰ) was 5.32％ high-grade cervical intraepithelial lesions (CIN Ⅱ/Ⅲ ) was 2.21％,cervical cancer was 0.12％.The prevalence of CIN Ⅰ was significantly higher than the CIN Ⅱ/Ⅲ (x2=134.15,P＜0.001 ).The prevalence of cervical cancer in 45- age group was 0.12％,the highest.HPV infection rates increased with the grades of cervical lesions including women without CIN as 44.31％,in CIN Ⅰ as 70.73％,in CIN Ⅱ as 86.73％,and in CIN Ⅲ as 96.75％ and in cancer as 100.00％.The HPV infection rates were different in districts (x2=17.81,P=0.03 ),with Futian and Luohu higher than those of Nanshan,Longgang and Baoan district.The prevalence rate of CIN in Baoan was lower than other districts.The CIN prevalence rates were not significantly different among the other districts of Shenzhen (x2=4.84,P=0.18).Conclusion The prevalence of cervical cancer was low in adult women living in Shenzhen,with cervical lesions still in the early stage.Prevention of HPV infection and treatment of CIN were the key points for the prevention of cervical cancer.
