中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
12期
1203-1206
,共4页
糖尿病肾微血管病变%辛伐他汀%阿司匹林%炎症因子
糖尿病腎微血管病變%辛伐他汀%阿司匹林%炎癥因子
당뇨병신미혈관병변%신벌타정%아사필림%염증인자
Diabetic renal microangipathy%Simvastatin%Aspirinon%Inflammation factor
目的 探讨糖尿病肾微血管病变患者血清P-选择素、肿瘤坏死因子-α(TNF-α)、高敏C-反应蛋白(hs-CRP)、白介素-1β(IL-1β)、细胞间粘附分子(ICAM)的临床意义及辛伐他汀联合阿司匹林治疗糖尿病肾微血管病变的机制.方法 用ELISA法测定各组以及糖尿病肾微血管病变组患者用辛伐他汀联合阿司匹林治疗后上述血清因子的变化水平.结果 ①糖尿病各组血清P-选择素、TNF-α、hs-CRP、IL-1β、ICAM均高于正常对照组(均P<0.01).②P-选择素、TNF-α、hs-CRP、IL-1β、ICAM在治疗8周时与治疗前比较均有明显下降(均P<0.05),治疗16周时进一步下降(P<0.01),以后保持稳定至21周.结论 ①P-选择素、TNF-α、hs-CRP、IL-1β、ICAM参与糖尿病肾微血管病变的发生发展,是糖尿病肾微血管病变的早期预测因子;②辛伐他汀联合阿司匹林治疗糖尿病肾微血管病变的机制可能是通过抑制炎症因子的表达,直接或间接影响系膜细胞增殖和系膜基质增生.
目的 探討糖尿病腎微血管病變患者血清P-選擇素、腫瘤壞死因子-α(TNF-α)、高敏C-反應蛋白(hs-CRP)、白介素-1β(IL-1β)、細胞間粘附分子(ICAM)的臨床意義及辛伐他汀聯閤阿司匹林治療糖尿病腎微血管病變的機製.方法 用ELISA法測定各組以及糖尿病腎微血管病變組患者用辛伐他汀聯閤阿司匹林治療後上述血清因子的變化水平.結果 ①糖尿病各組血清P-選擇素、TNF-α、hs-CRP、IL-1β、ICAM均高于正常對照組(均P<0.01).②P-選擇素、TNF-α、hs-CRP、IL-1β、ICAM在治療8週時與治療前比較均有明顯下降(均P<0.05),治療16週時進一步下降(P<0.01),以後保持穩定至21週.結論 ①P-選擇素、TNF-α、hs-CRP、IL-1β、ICAM參與糖尿病腎微血管病變的髮生髮展,是糖尿病腎微血管病變的早期預測因子;②辛伐他汀聯閤阿司匹林治療糖尿病腎微血管病變的機製可能是通過抑製炎癥因子的錶達,直接或間接影響繫膜細胞增殖和繫膜基質增生.
목적 탐토당뇨병신미혈관병변환자혈청P-선택소、종류배사인자-α(TNF-α)、고민C-반응단백(hs-CRP)、백개소-1β(IL-1β)、세포간점부분자(ICAM)적림상의의급신벌타정연합아사필림치료당뇨병신미혈관병변적궤제.방법 용ELISA법측정각조이급당뇨병신미혈관병변조환자용신벌타정연합아사필림치료후상술혈청인자적변화수평.결과 ①당뇨병각조혈청P-선택소、TNF-α、hs-CRP、IL-1β、ICAM균고우정상대조조(균P<0.01).②P-선택소、TNF-α、hs-CRP、IL-1β、ICAM재치료8주시여치료전비교균유명현하강(균P<0.05),치료16주시진일보하강(P<0.01),이후보지은정지21주.결론 ①P-선택소、TNF-α、hs-CRP、IL-1β、ICAM삼여당뇨병신미혈관병변적발생발전,시당뇨병신미혈관병변적조기예측인자;②신벌타정연합아사필림치료당뇨병신미혈관병변적궤제가능시통과억제염증인자적표체,직접혹간접영향계막세포증식화계막기질증생.
Objective To investigate the clinical significance of serum P-selection,TNF-α,hs-CRP,IL-1β, ICAM in patients with diabetic renal microangipathy, and the therapeutic mechanism of Simvastatin combined with aspirinon in treating renal microangipathy. Methods The serum levels of P-selection,TNF-α, hs-CRP, IL-1β, ICAM were determined by ELISA in all groups. Patients with diabetic renal microangipathy treated with simvastatin and as-pirinon. Results ① The serum levels of P-selection,TNF-α,hs-CRP,IL-1β,ICAM in DM groups were higher than those of normal controls(P<0.01). ②After treatment with simvastatin and aspirinon for 8 weeks in patients with di-abetic nephropathy,the serum levels of P-selection, TNF-α, hs-CRP, IL-1β, ICAM were all decreased significantly compared with those before treatment respectively (P<0.01). After treatment for 16 weeks the above indices re-mained decreased until treatment for 21 weeks (P<0.01). Conclusion ①The plasma levels of Poselection,TNF-α and hs-CRP, IL-1β, ICAM are correlated to the occurance and development of diabetic renal microangiopathy, becom-ing predicted factors in early stage of diabetic renal microangiopathy. ②The therapeutic mechanism of simvastatin and aspirinon in patients with diabetic nephropathy lies probably in the inhibition of these factors expression, thus di-rectly or indirectly affecting the prolffer-ation of mesangial cells and mesangial matrix.
