中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2011年
6期
880-882
,共3页
张一川%何乐业%龙智%孙晓辉%王国民%裴夏明%钟狂飚
張一川%何樂業%龍智%孫曉輝%王國民%裴夏明%鐘狂飚
장일천%하악업%룡지%손효휘%왕국민%배하명%종광표
前列腺增生症%逼尿肌纤维化%转换生长因子-β1%结缔组织生长因子
前列腺增生癥%逼尿肌纖維化%轉換生長因子-β1%結締組織生長因子
전렬선증생증%핍뇨기섬유화%전환생장인자-β1%결체조직생장인자
Benign prostatic hyperplasia%Detrusor fibrosis%Transforming growth factor-β1%Connective tissue growth factor
目的 探讨良性前列腺增生症(BPH)患者逼尿肌中转化生长因子-β1(TGF-β1)和结缔组织生长因子(CTGF)的表达及临床意义.方法 应用免疫组织化学SP法检测29例BPH患者膀胱逼尿肌标本中TGF-β1和CTGF的表达并检测平均吸光度(MA),依据各临床参数参考值进行分组比较.结果 所有标本均有不同程度的TGF-β1和CTGF表达.前列腺体积(PV)＞50 ml组与PV≤50 ml组患者逼尿肌中TGF-β1的表达差异无统计学意义(P＞0.05);而CTGF在PV＞50 ml组的表达量显著高于PV≤50 ml组(P＜0.01).TGF-β1和CTGF的表达量在移行区指数(TZI)＞0.65、残余尿量＞50 ml组患者逼尿肌中分别高于TZI≤0.65、残余尿量≤50 ml(P＜0.01),而与IPSS、Qmax和病程大小无明显相关(P＞0.05).Pearson积差相关分析可见TGF-β1与CTGF的表达呈正相关(r=0.761,P＜0.01).结论 逼尿肌中TGF-β1和CTGF的高表达与前列腺体积、移行区指数及残余尿量相关,提示这些临床参数可作为评估BPH患者膀胱逼尿肌纤维化程度的指标.
目的 探討良性前列腺增生癥(BPH)患者逼尿肌中轉化生長因子-β1(TGF-β1)和結締組織生長因子(CTGF)的錶達及臨床意義.方法 應用免疫組織化學SP法檢測29例BPH患者膀胱逼尿肌標本中TGF-β1和CTGF的錶達併檢測平均吸光度(MA),依據各臨床參數參攷值進行分組比較.結果 所有標本均有不同程度的TGF-β1和CTGF錶達.前列腺體積(PV)＞50 ml組與PV≤50 ml組患者逼尿肌中TGF-β1的錶達差異無統計學意義(P＞0.05);而CTGF在PV＞50 ml組的錶達量顯著高于PV≤50 ml組(P＜0.01).TGF-β1和CTGF的錶達量在移行區指數(TZI)＞0.65、殘餘尿量＞50 ml組患者逼尿肌中分彆高于TZI≤0.65、殘餘尿量≤50 ml(P＜0.01),而與IPSS、Qmax和病程大小無明顯相關(P＞0.05).Pearson積差相關分析可見TGF-β1與CTGF的錶達呈正相關(r=0.761,P＜0.01).結論 逼尿肌中TGF-β1和CTGF的高錶達與前列腺體積、移行區指數及殘餘尿量相關,提示這些臨床參數可作為評估BPH患者膀胱逼尿肌纖維化程度的指標.
목적 탐토량성전렬선증생증(BPH)환자핍뇨기중전화생장인자-β1(TGF-β1)화결체조직생장인자(CTGF)적표체급림상의의.방법 응용면역조직화학SP법검측29례BPH환자방광핍뇨기표본중TGF-β1화CTGF적표체병검측평균흡광도(MA),의거각림상삼수삼고치진행분조비교.결과 소유표본균유불동정도적TGF-β1화CTGF표체.전렬선체적(PV)＞50 ml조여PV≤50 ml조환자핍뇨기중TGF-β1적표체차이무통계학의의(P＞0.05);이CTGF재PV＞50 ml조적표체량현저고우PV≤50 ml조(P＜0.01).TGF-β1화CTGF적표체량재이행구지수(TZI)＞0.65、잔여뇨량＞50 ml조환자핍뇨기중분별고우TZI≤0.65、잔여뇨량≤50 ml(P＜0.01),이여IPSS、Qmax화병정대소무명현상관(P＞0.05).Pearson적차상관분석가견TGF-β1여CTGF적표체정정상관(r=0.761,P＜0.01).결론 핍뇨기중TGF-β1화CTGF적고표체여전렬선체적、이행구지수급잔여뇨량상관,제시저사림상삼수가작위평고BPH환자방광핍뇨기섬유화정도적지표.
Objective To investigate the correlation between the expression of transforming growth factor-β1 (TGF-β1 ) , connective tissue growth factor ( CTGF) in the detrusor of benign prostatic hyperplasia (BPH) patients and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of TGF-β1 and CTGF in 29 specimens of bladder wall of BPH patients. All patients were divided into 2 groups according to the meaningful value of each clinical parameter to compare the expression of TGF-β1 and CTGF. Results All the samples had different levels of TGF-β1 and CTGF expression. The TGF-β1 in BPH patients whose prostate volume (PV) was＞50 ml was not significantly different from that in patients whose PV was ≤50 ml, but CTGF in BPH patients with PV ＞50 ml was higher than that in the other team. The TGF-β1 and CTGF in groups with TZI ＞0. 65 and residual urine＞50 ml were higher than other groups with TZI ≤0. 65 and residual urine ≤50 ml, respectively. The expression levels of TGF-β1 and CTGF of detrusors were not related with IPSS, Qmax, disease duration (P＞0. 05).Pearson-analysis reavealed that there was a positive correlation between the expression of TGF-β1 and CTGF in detrusors (r = 0. 761 ,P ＜0. 01). Conclusion TGF-β1 and CTGF have a strong correlation with PV, TZI and residual urine, suggesting that these clinical parameters may be useful in assessing the degree of the detrusor fibrosis in BPH patients.
